antibody

DCLK1 Antibody

MBS151052

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

DCLK1 Antibody

DCLK1

DCLK1; CL1; DCLK; CLICK1; DCDC3A; DCAMKL1; KIAA0369; Doublecortin domain-containing protein 3A; doublecortin-like kinase 1

serine/threonine-protein kinase DCLK1 isoform 1; Serine/threonine-protein kinase DCLK1; serine/threonine-protein kinase DCLK1; doublecortin-like and CAM kinase-like 1; doublecortin domain-containing protein 3A; doublecortin-like kinase 1; Doublecortin domain-containing protein 3A; Doublecortin-like and CAM kinase-like 1; Doublecortin-like kinase 1

DCLK1

DCLK1; DCLK1; CL1; DCLK; CLICK1; DCDC3A; DCAMKL1; DCAMKL1; DCDC3A; KIAA0369

DCLK1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

729

DCLK1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

DCLK1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

DCLK1 antibody can be used for detection of DCLK1 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.

Conjugate: Unconjugated. Immunogen: DCLK1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human DCLK1. Buffer: DCLK1 Antibody is supplied in PBS containing 0.02% sodium azide.

DCLK1 Antibody: DCLK1 is one of three doublecortin-like kinases similar to the Ca2+/calmodulin-dependent protein kinase (CaMK) family. DCLK1 mRNA, like that of the homologous DCLK2 and DCLK3, is highly expressed in adult brain, but only DCLK1 and DCLK2 transcripts are present in human fetal brain and the developing mouse embryo, suggesting that DCLK1 and DCLK2 may play roles in cortical development. The DCLK proteins are homologous to Doublecortin (DCX), a gene that is mutated in X-linked human lissencephaly. In mouse models where the DCX gene has been disrupted, DCLK1 expression increases slightly and appears to compensate for the loss of DCX, as mice mutant for both DCX and DCLK1 show a severe phenotype including perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization. Unlike DCLK1, DCLK2 expression does not change in DCX-null mice.

4758128

NP_004725

NM_004734.4

O15075

47,681 Da

This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

0.1 mg

345 USD