TET3 Antibody | MyBioSource MBS151041 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TET3 Antibody

catalog :

MBS151041

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS151041

products type :

Antibody

products full name :

TET3 Antibody

products short name :

TET3

products name syn :

TET3; hCG_40738; KIAA0401; Methylcytosine dioxygenase TET3; TET methylcytosine dioxygenase 3

other names :

Methylcytosine dioxygenase TET3; methylcytosine dioxygenase TET3; tet methylcytosine dioxygenase 3

products gene name :

TET3

other gene names :

TET3; TET3; hCG_40738; KIAA0401

uniprot entry name :

TET3_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

727

specificity :

At least three isoforms of TET3 are known to exist. TET3 antibody is predicted to not cross react with other TET proteins.

purity :

TET3 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

TET3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

app notes :

TET3 antibody can be used for detection of TET3 by Western blot at 1 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: TET3 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TET3. Buffer: TET3 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

TET3 Antibody: TET3, a member of the ten-eleven-translocation (TET) family of genes, is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine and is most abundantly expressed in hematopoietic cells. Unlike the related TET2 protein, mutations in TET3 have not been observed in any myeloid malignancies. TET3 has been shown to be involved in the demethylation of zygotic DNA before the first mitosis and has been suggested to be involved in the epigenetic reprogramming of the zygotic paternal DNA following natural fertilization and may also contribute to somatic cell nuclear reprogramming during animal cloning.

ncbi gi num :

149944516

ncbi acc num :

NP_659430

ncbi gb acc num :

NM_144993.1

uniprot acc num :

O43151

ncbi mol weight :

183 kDa

ncbi pathways :

Epigenetic Regulation Of Gene Expression Pathway (1127671); Gene Expression Pathway (105937); TET1,2,3 And TDG Demethylate DNA Pathway (1127673)

ncbi summary :

Members of the ten-eleven translocation (TET) gene family, including TET3, play a role in the DNA methylation process (Langemeijer et al., 2009 [PubMed 19923888]).[supplied by OMIM, Nov 2010]

uniprot summary :

TET3: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Conversion into 5hmC initiates a process leading to cytosine demethylation through deamination into 5-hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. Belongs to the TET family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Oxidoreductase; EC 1.14.11.n2. Chromosomal Location of Human Ortholog: 2p13.1. Cellular Component: male pronucleus; cytoplasm; female pronucleus. Molecular Function: protein binding; DNA binding; metal ion binding. Biological Process: protein amino acid O-linked glycosylation; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of gene expression, epigenetic

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage