SLC35D2 Antibody | MyBioSource MBS151008 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

SLC35D2 Antibody

catalog :

MBS151008

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS151008

products type :

Antibody

products full name :

SLC35D2 Antibody

products short name :

SLC35D2

products name syn :

SLC35D2; hfrc; HFRC1; SQV7L; UGTrel8; HFRC; UGTREL8; Homolog of Fringe connection protein 1; solute carrier family 35, member D2

other names :

UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter isoform a; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; SQV7-like protein; fringe connection; UDP-N-acetylglucosamine transporter; solute carrier family 35, member D2; homolog of Fringe connection protein 1; UDP-galactose transporter-related protein 8; solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2; Homolog of Fringe connection protein 1; HFRC1; SQV7-like protein; SQV7L; Solute carrier family 35 member D2; UDP-galactose transporter-related protein 8; UGTrel8

products gene name :

SLC35D2

other gene names :

SLC35D2; SLC35D2; hfrc; HFRC1; SQV7L; UGTrel8; HFRC; UGTREL8; HFRC1; SQV7L; UGTrel8

uniprot entry name :

S35D2_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

337

specificity :

At least two isoforms of SLC35D2 are known to exist; this antibody will recognize both isoforms. SLC35D2 antibody is predicted to not cross-react with SLC35D1 or SLC35D3.

purity :

SLC35D2 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

SLC35D2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

app notes :

SLC35D2 antibody can be used for detection of SLC35D2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: SLC35D2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human SLC35D2. Buffer: SLC35D2 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

SLC35D2 Antibody: The solute carrier family SLC35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident SLC family member SLC35D2 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. Its overexpression in transfected cells modulated cell surface heparin sulfate expression, suggesting that SLC35D2 is involved in heparin sulfate synthesis. SLC35D2-overexpressing cells also showed increased constitutive and hypotonic stress-stimulated release of UDP-GlcNAc, suggesting that SLC35D2 may be involved in UDP-sugar release and cell signaling.

ncbi gi num :

223029426

ncbi acc num :

NP_008932

ncbi gb acc num :

NM_007001.2

uniprot acc num :

Q76EJ3

ncbi mol weight :

26,702 Da

ncbi pathways :

Defective B3GAT3 Causes JDSSDHD Pathway (1127588); Defective B4GALT1 Causes B4GALT1-CDG (CDG-2d) Pathway (1127592); Defective B4GALT7 Causes EDS, Progeroid Type Pathway (1127587); Defective CHST14 Causes EDS, Musculocontractural Type Pathway (1127591); Defective CHST3 Causes SEDCJD Pathway (1127590); Defective CHST6 Causes MCDC1 Pathway (1127593); Defective CHSY1 Causes TPBS Pathway (1127589); Defective EXT1 Causes Exostoses 1, TRPS2 And CHDS Pathway (1127594); Defective EXT2 Causes Exostoses 2 Pathway (1127595); Defective PAPSS2 Causes SEMD-PA Pathway (1127586)

ncbi summary :

Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

uniprot summary :

SLC35D2: Antiporter transporting nucleotide sugars such as UDP-N- acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) and GDP- mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleosides monophosphates (UMP for UDP-sugars and GMP for GDP-sugars). May take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, and thus be involved in growth factor signaling. Belongs to the TPT transporter family. SLC35D subfamily. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 9q22.32. Cellular Component: Golgi membrane; integral to membrane. Molecular Function: nucleotide-sugar transmembrane transporter activity. Biological Process: keratan sulfate metabolic process; glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate transport; carbohydrate metabolic process; keratan sulfate biosynthetic process; pathogenesis; transmembrane transport

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage