antibody

TRESK Antibody

MBS150974

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

TRESK Antibody

TRESK

TRESK; TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2; TRIK; Potassium channel subfamily K member 18; TWIK-related individual potassium channel; potassium channel, subfamily K, member 18

potassium channel subfamily K member 18; Potassium channel subfamily K member 18; potassium channel subfamily K member 18; TWIK-related individual K+ channel; TWIK-related spinal cord K+ channel; TWIK-related individual potassium channel; potassium channel, subfamily K, member 18; TWIK-related spinal cord potassium channel; potassium channel, two pore domain subfamily K, member 18; TWIK-related individual potassium channel; TWIK-related spinal cord potassium channel

KCNK18

KCNK18; KCNK18; TRIK; MGR13; TRESK; TRESK2; K2p18.1; TRESK-2; TRESK; TRIK

KCNKI_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

384

TRESK Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TRESK antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

TRESK antibody can be used for detection of TRESK by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: TRESK antibody was raised against a 17 amino acid synthetic peptide from near the center of human TRESK. Buffer: TRESK Antibody is supplied in PBS containing 0.02% sodium azide.

TRESK Antibody: TRESK (TWIK-related spinal cord K+ channel) is a two-pore domain K+ channel that induces outward rectification and functions as a background K+ channel that is abundantly expressed in the spinal cord, thymus, spleen, and leukemic T-lymphocytes. TRESK is activated by increased cytoplasmic calcium concentration through calcineurin as well as by acetylcholine and histamine. It has been suggested that TRESK is linked to acute and chronic pain by activation of calcineurin. Other studies indicate that TRESK may play a role in the regulation of T-cell function and could be an excellent target to treat T-cell originated immune dysfunction.

32469495

NP_862823

NM_181840.1

Q7Z418

43,671 Da

Neuronal System Pathway 106513!!Potassium Channels Pathway 366221!!TWIK-related Spinal Cord K+ Channel (TRESK) Pathway 366236!!Tandem Pore Domain Potassium Channels Pathway 366231

Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura.[provided by RefSeq, Jan 2011]

0.1 mg

345 USD