AES Antibody | MyBioSource MBS150968 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

AES Antibody

catalog :

MBS150968

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150968

products type :

Antibody

products full name :

AES Antibody

products short name :

AES

products name syn :

AES; GRG; ESP1; GRG5; TLE5; AES-1; AES-2; GRG; Amino-terminal enhancer of split; Gp130-associated protein GAM; Amino enhancer of split; amino-terminal enhancer of split

other names :

amino-terminal enhancer of split isoform a; Amino-terminal enhancer of split; amino-terminal enhancer of split; groucho-related protein 5; gp130-associated protein GAM; amino-terminal enhancer of split; Gp130-associated protein GAM; Grg-5; Groucho-related protein 5; Protein ESP1; Protein GRG

products gene name :

AES

other gene names :

AES; AES; GRG; ESP1; GRG5; TLE5; AES-1; AES-2; Grg-5; GRG; GRG5; Amino enhancer of split

uniprot entry name :

AES_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

264

purity :

AES Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

AES antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

AES antibody can be used for the detection of AES by Western blot at 1 - 4 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: AES antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human AES. Buffer: AES Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

ncbi gi num :

39812019

ncbi acc num :

NP_945320

ncbi gb acc num :

NM_198969.1

uniprot acc num :

Q08117

ncbi mol weight :

29,091 Da

ncbi pathways :

AMER1 Mutants Destabilize The Destruction Complex Pathway 1127621!!APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway 1127616!!APC Truncation Mutants Have Impaired AXIN Binding Pathway 1127617!!AXIN Missense Mutants Destabilize The Destruction Complex Pathway 1127620!!AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway 1127618!!Androgen Receptor Signaling Pathway 198806!!Degradation Of Beta-catenin By The Destruction Complex Pathway 106511!!Disease Pathway 530764!!Presenilin Action In Notch And Wnt Signaling Pathway 137914!!Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway 169352

ncbi summary :

The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

345 USD

more info or order :

MyBioSource product webpage