product summary
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company name :
MyBioSource
product type :
antibody
product name :
SPT2 Antibody
catalog :
MBS150966
quantity :
0.1 mg
price :
345 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS150966
products type :
Antibody
products full name :
SPT2 Antibody
products short name :
SPT2
products name syn :
SPT2; LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a; KIAA0526; LCB2; Serine palmitoyltransferase 2; Long chain base biosynthesis protein 2; LCB 2; serine palmitoyltransferase, long chain base subunit 2
other names :
serine palmitoyltransferase 2; Serine palmitoyltransferase 2; serine palmitoyltransferase 2; LCB 2; SPT 2; serine-palmitoyl-CoA transferase 2; long chain base biosynthesis protein 2a; serine palmitoyltransferase, subunit II; serine palmitoyltransferase, long chain base subunit 2; Long chain base biosynthesis protein 2; LCB 2; Long chain base biosynthesis protein 2a; LCB2a; Serine-palmitoyl-CoA transferase 2; SPT 2
products gene name :
SPTLC2
other gene names :
SPTLC2; SPTLC2; LCB2; SPT2; HSN1C; LCB2A; NSAN1C; hLCB2a; KIAA0526; LCB2; LCB 2; LCB2a; SPT 2
uniprot entry name :
SPTC2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human, Mouse, Rat
sequence length :
562
specificity :
At least three isoforms of SPT2 are known to exist; this antibody will not detect isoform b. SPT2 antibody is predicted to not cross-react with SPT1.
purity :
SPT2 Antibody is affinity chromatography purified via peptide column.
form :
Liquid
concentration :
1 mg/mL
storage stability :
SPT2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
app notes :
SPT2 antibody can be used for detection of SPT2 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: SPT2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human SPT2. Buffer: SPT2 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
SPT2 Antibody: Serine palmitoyltransferase (SPT), which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It converts L-serine and palmitoyl-CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. SPT2 is the long chain base subunit 2 of mammalian serine palmitoyltransferase. SPT2 is catalytically active but needs its related protein SPT1 for its stabilization and anchoring the holoenzyme to the cytosolic face of the endoplasmic reticulum. As in the case with SPT1, mutations in the SPT2 gene can cause hereditary sensory and autonomic neuropathy type I (HSAN-I), resulting from a loss of SPT activity as well as the accumulation of the atypical and neurotoxic sphingoid metabolite 1-deoxy-sphinganine.
ncbi gi num :
4758668
ncbi acc num :
NP_4854
ncbi gb acc num :
NM_004863.3
uniprot acc num :
O15270
ncbi mol weight :
62,924 Da
ncbi pathways :
Ceramide Biosynthesis Pathway 524496!!Ceramide Biosynthesis Pathway 468287!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Lipids And Lipoproteins Pathway 160976!!Sphingolipid Metabolism Pathway 760636!!Sphingolipid De Novo Biosynthesis Pathway 530750!!Sphingolipid Metabolism Pathway 82994!!Sphingolipid Metabolism Pathway 119543!!Sphingolipid Metabolism Pathway 369
ncbi summary :
This gene encodes a long chain base subunit of serine palmitoyltransferase. Serine palmitoyltransferase, which consists of two different subunits, is the key enzyme in sphingolipid biosynthesis. It catalyzes the pyridoxal-5-prime-phosphate-dependent condensation of L-serine and palmitoyl-CoA to 3-oxosphinganine. Mutations in this gene were identified in patients with hereditary sensory neuropathy type I. [provided by RefSeq, Mar 2011]
size :
0.1 mg
price :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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