antibody

ASC Antibody

MBS150936

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

ASC Antibody

ASC

ASC; ASC; TMS; TMS1; CARD5; TMS-1; ASC; Apoptosis-associated speck-like protein containing a CARD; Caspase recruitment domain-containing protein 5; hASC; PYD and CARD domain containing

apoptosis-associated speck-like protein containing a CARD; Apoptosis-associated speck-like protein containing a CARD; apoptosis-associated speck-like protein containing a CARD; target of methylation-induced silencing 1; caspase recruitment domain-containing protein 5; PYD and CARD domain containing; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1

PYCARD

PYCARD; PYCARD; ASC; TMS; TMS1; CARD5; TMS-1; ASC; CARD5; TMS1; hASC

ASC_HUMAN

Polyclonal

IgG

Rabbit

Human

195

ASC Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

ASC antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

ASC antibody can be used for detection of ASC/TMS1 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL.

Conjugate: Unconjugated. Immunogen: ASC antibody was raised against a 14 amino acid peptide near the carboxy terminus of human ASC. Buffer: ASC Antibody is supplied in PBS containing 0.02% sodium azide.

ASC Antibody: Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD containing cell death regulators include RAIDD, RICK, BCL10, Apaf-1, ARC, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified in human and mouse and designated ASC and TMS1. Ectopic expression of ASC/TMS1 induced apoptosis through activation of caspase-9 and inhibited the survival of human breast cancer cells (3, 4). Overexpression of ASC/TMS1 induced DNA fragmentation. ASC/TMS1 is expressed in a variety of human and mouse tissues.

10801602

BAA87339

Q9ULZ3

25 kDa

Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Direct P53 Effectors Pathway 137939!!Immune System Pathway 106386!!Inflammasomes Pathway 366166!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Innate Immune System Pathway 106387!!Legionellosis Pathway 469200!!Legionellosis Pathway 469186

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD