antibody

ATF6 Antibody

MBS150934

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

ATF6 Antibody

ATF6

ATF6; ATF6A; Cyclic AMP-dependent transcription factor ATF-6 alpha; Activating transcription factor 6 alpha; cAMP-dependent transcription factor ATF-6 alpha; activating transcription factor 6

cyclic AMP-dependent transcription factor ATF-6 alpha; Cyclic AMP-dependent transcription factor ATF-6 alpha; cyclic AMP-dependent transcription factor ATF-6 alpha; cAMP-dependent transcription factor ATF-6 alpha; activating transcription factor 6; Activating transcription factor 6 alpha; ATF6-alpha

ATF6

ATF6; ATF6; ATF6A; cAMP-dependent transcription factor ATF-6 alpha; ATF6-alpha

ATF6A_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

670

ATF6 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

ATF6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

ATF6 antibody can be used for the detection of ATF6 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: ATF6 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human ATF6. Buffer: ATF6 Antibody is supplied in PBS containing 0.02% sodium azide.

ATF6 Antibody: Disruptions of protein folding and maturation in the endoplasmic reticulum (ER) result in the activation of the unfolded protein response (UPR), an integrated cellular signaling pathway that transmits information from the ER lumen to the cytoplasm and nucleus. Activating transcription factor 6 (ATF6) as well as the ER-transmembrane protein kinases IRE1p and PERK are the major transducers of the UPR. ATF6 is an ER transmembrane protein that is normally bound to the ER chaperone GRP78, but upon ER stress is released from GRP78 and proteolytically cleaved to yield a cytosolic fragment which then migrates to the nucleus, and together with the transcription factor XBP-1, activates transcription of UPR-responsive genes. ATF6 has two isoforms (ATF6 and ATF6 only ATF6 is recognized by this antibody.

56786157

NP_031374

NM_007348.3

P18850

74,585 Da

ATF4 Activates Genes Pathway 530772!!ATF6-alpha Activates Chaperone Genes Pathway 530770!!ATF6-alpha Activates Chaperones Pathway 105905!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Metabolism Of Proteins Pathway 106230!!PERK Regulates Gene Expression Pathway 105907!!Protein Processing In Endoplasmic Reticulum Pathway 167325!!Protein Processing In Endoplasmic Reticulum Pathway 167190

This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis. [provided by RefSeq, Aug 2011]

0.1 mg

345 USD