antibody

VKORC1 Antibody

MBS150932

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

VKORC1 Antibody

VKORC1

VKORC1; VKOR; MST134; MST576; VKCFD2; EDTP308; IMAGE3455200; VKOR; MSTP134; MSTP576; UNQ308/PRO351; Vitamin K epoxide reductase complex subunit 1; Vitamin K1 2; 3-epoxide reductase subunit 1; vitamin K epoxide reductase complex, subunit 1

vitamin K epoxide reductase complex subunit 1 isoform 1; Vitamin K epoxide reductase complex subunit 1; vitamin K epoxide reductase complex subunit 1; phylloquinone epoxide reductase; vitamin K1 2,3-epoxide reductase subunit 1; vitamin K dependent clotting factors deficiency 2; vitamin K1 epoxide reductase (warfarin-sensitive); vitamin K epoxide reductase complex, subunit 1; Vitamin K1 2,3-epoxide reductase subunit 1

VKORC1

VKORC1; VKORC1; VKOR; MST134; MST576; VKCFD2; EDTP308; IMAGE3455200; VKOR

VKOR1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

163

VKORC1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

VKORC1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

VKORC1 antibody can be used for detection of VKORC1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 5 mug/mL.

Conjugate: Unconjugated. Immunogen: VKORC1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human VKORC1. Buffer: VKORC1 Antibody is supplied in PBS containing 0.02% sodium azide.

VKORC1 Antibody: Vitamin K epoxide reductase complex subunit 1 (VKORC1) is the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form which is essential for blood clotting. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is VKORC1 that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance.

13124770

NP_076869

NM_024006.4

Q9BQB6

9,875 Da

Gamma Carboxylation, Hypusine Formation And Arylsulfatase Activation Pathway (106231); Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway (106232); Metabolism Of Proteins Pathway (106230); Post-translational Protein Modification Pathway (161012); Ubiquinone And Other Terpenoid-quinone Biosynthesis Pathway (82939); Ubiquinone And Other Terpenoid-quinone Biosynthesis Pathway (300)

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

VKORC1: Involved in vitamin K metabolism. Catalytic subunit of the vitamin K epoxide reductase (VKOR) complex which reduces inactive vitamin K 2,3-epoxide to active vitamin K. Defects in VKORC1 are a cause of combined deficiency of vitamin K-dependent clotting factors type 2 (VKCFD2). VKCFD leads to a bleeding tendency that is usually reversed by oral administration of vitamin K. Defects in VKORC1 are a cause of coumarin resistance (CMRES). A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. Belongs to the VKOR family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, multi-pass; EC 1.1.4.1; Oxidoreductase; Membrane protein, integral; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 16p11.2. Cellular Component: endoplasmic reticulum membrane; integral to membrane. Molecular Function: vitamin-K-epoxide reductase (warfarin-sensitive) activity; quinone binding. Biological Process: cellular protein metabolic process; vitamin K metabolic process; post-translational protein modification; blood coagulation; drug metabolic process; peptidyl-glutamic acid carboxylation. Disease: Coumarin Resistance; Vitamin K-dependent Clotting Factors, Combined Deficiency Of, 2

0.1 mg

345 USD