antibody

PRDM16 Antibody

MBS150905

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

PRDM16 Antibody

PRDM16

PRDM16; MEL1; LVNC8; PFM13; CMD1LL; KIAA1675; MEL1; PR domain zinc finger protein 16; PR domain-containing protein 16; PR domain containing 16

PR domain zinc finger protein 16; PR domain zinc finger protein 16; MDS1/EVI1-like gene 1; transcription factor MEL1; PR domain containing 16; PR domain-containing protein 16; Transcription factor MEL1; MDS1/EVI1-like gene 1

PRDM16

PRDM16; PRDM16; MEL1; LVNC8; PFM13; CMD1LL; KIAA1675; MEL1; PFM13; MDS1/EVI1-like gene 1

PRD16_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

1,092

PRDM16 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

PRDM16 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

PRDM16 antibody can be used for detection of PRDM16 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: PRDM16 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human PRDM16. Buffer: PRDM16 Antibody is supplied in PBS containing 0.02% sodium azide.

PRDM16 Antibody: PRDM16 is a zinc finger transcription factor and contains an N-terminal PR domain. The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36, q21)-positive MDS/AML. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Recent studies have shown that PRDM16 normally acts as a Smad3 binding protein that may be important for the development of orofacial structures through modulation of the TGF-beta signaling pathway. Other experiments have indicated that PRDM16 controls a bidirectional cell fate switch between skeletal myoblasts and brown fat cells.

55665817

CAH71530

Q9HAZ2

120,338 Da

The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD