TRPC6 Antibody | MyBioSource MBS150882 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

TRPC6 Antibody

catalog :

MBS150882

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150882

products type :

Antibody

products full name :

TRPC6 Antibody

products short name :

TRPC6

products name syn :

TRPC6; TRP6; FSGS2; TRP6; Short transient receptor potential channel 6; Transient receptor protein 6; TrpC6; transient receptor potential cation channel, subfamily C, member 6

other names :

Transient receptor potential cation channel, subfamily C, member 6; Short transient receptor potential channel 6; short transient receptor potential channel 6; TRP-6; transient receptor protein 6; focal segmental glomerulosclerosis 2; transient receptor potential cation channel, subfamily C, member 6; Transient receptor protein 6; TRP-6

products gene name :

TRPC6

other gene names :

TRPC6; TRPC6; TRP6; FSGS2; TRP6; TrpC6; TRP-6

uniprot entry name :

TRPC6_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

931

specificity :

This antibody may cross-react with TRPC3.

purity :

TRPC6 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

TRPC6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

TRPC6 antibody can be used for the detection of TRPC6 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: TRPC6 antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human TRPC6. Buffer: TRPC6 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

TRPC6 Antibody: The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP" (TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC6/6/7 subfamily can be activated by diacylglycerol (DAG) analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. When expressed in transfected cells, TRPC6 acts as a non-selective store-independent receptor-activated cation channel. It is activated by DAG in a PKC-independent manner and is insensitive to IP3 activation. There is increasing evidence that TRPC6 encodes endogenous DAG-activated receptor-operated cation channels in vivo.

ncbi gi num :

62739910

ncbi acc num :

AAH93658

uniprot acc num :

Q9Y210

ncbi mol weight :

Predicted: 100; 102 kDa. Observed: 93 kDa

ncbi pathways :

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); EPO Signaling Pathway (138051); Effects Of PIP2 Hydrolysis Pathway (106044); Elevation Of Cytosolic Ca2+ Levels Pathway (106047); Endothelins Pathway (137958); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Hemostasis Pathway (106028)

ncbi summary :

The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]

uniprot summary :

TRPC6: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Seems not to be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Expressed primarily in placenta, lung, spleen, ovary and small intestine. Expressed in podocytes and is a component of the glomerular slit diaphragm. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Channel, cation; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 11q22.1. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding; store-operated calcium channel activity. Biological Process: positive regulation of ion transmembrane transporter activity; platelet activation; axon guidance; elevation of cytosolic calcium ion concentration; blood coagulation; positive regulation of calcium ion transport; transmembrane transport; cation transport; aging. Disease: Focal Segmental Glomerulosclerosis 2

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage