CAPS1 Antibody | MyBioSource MBS150862 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

CAPS1 Antibody

catalog :

MBS150862

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150862

products type :

Antibody

products full name :

CAPS1 Antibody

products short name :

CAPS1

products name syn :

CAPS1; CAPS; CAPS1; CADPS1; CAPS; KIAA1121; Calcium-dependent secretion activator 1; Calcium-dependent activator protein for secretion 1; CAPS-1; Ca++-dependent secretion activator

other names :

calcium-dependent secretion activator 1 isoform 2; Calcium-dependent secretion activator 1; calcium-dependent secretion activator 1; CAPS-1; Ca2+-dependent secretion activator; Ca2+-regulated cytoskeletal protein; Ca2+-dependent activator protein for secretion; calcium-dependent activator protein for secretion 1; Ca++-dependent secretion activator; Calcium-dependent activator protein for secretion 1; CAPS-1

products gene name :

CADPS

other gene names :

CADPS; CADPS; CAPS; CAPS1; CADPS1; CAPS; CAPS1; KIAA1121; CAPS-1

uniprot entry name :

CAPS1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1314

specificity :

Numerous isoforms of CAPS1 are known to exist; the lower molecular weight bands seen in the immunoblot image are likely to be these isoforms. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.

purity :

CAPS1 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

CAPS1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

CAPS1 antibody can be used for detection of CAPS1 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: CAPS1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human CAPS1. Buffer: CAPS1 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

CAPS1 Antibody: CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.

ncbi gi num :

34452713

ncbi acc num :

NP_899631

ncbi gb acc num :

NM_183394.2

uniprot acc num :

Q9ULU8

ncbi mol weight :

50,236 Da

ncbi summary :

This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]

uniprot summary :

CADPS: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. 5 isoforms of the human protein are produced by alternative splicing. Protein type: Vesicle. Chromosomal Location of Human Ortholog: 3p14.2. Cellular Component: cytoplasmic vesicle membrane; synapse; cytosol; cell junction. Molecular Function: protein binding; metal ion binding; lipid binding; protein kinase binding. Biological Process: catecholamine secretion; protein transport; exocytosis; vesicle organization and biogenesis; synaptic vesicle priming

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage