antibody

Unc93b Antibody

MBS150832

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

Unc93b Antibody

Unc93b

Unc93b; IIAE1; UNC93; UNC93B; Unc-93B1; Protein unc-93 homolog B1; unc-93 homolog B1 (C. elegans)

UNC93B1 protein, partial; Protein unc-93 homolog B1; protein unc-93 homolog B1; unc93 homolog B1; unc-93 related protein; unc-93 homolog B1 (C. elegans)

UNC93B1

UNC93B1; UNC93B1; IIAE1; UNC93; UNC93B; Unc-93B1; UNC93; UNC93B; Unc-93B1; hUNC93B1

UN93B_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

505

Multiple isoforms of Unc93b are known to exist. This antibody will not cross-react with Unc93a.

Unc93b Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

Unc93b antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Unc93b antibody can be used for the detection of Unc93b by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: Unc93b antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Unc93b. Buffer: Unc93b Antibody is supplied in PBS containing 0.02% sodium azide.

Unc93b Antibody: The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b plays an important role in innate immunity.

116284350

AAH33623

Q9H1C4

56; 66 kDa

Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Toll-Like Receptors Cascades Pathway 106388!!Trafficking And Processing Of Endosomal TLR Pathway 576253

This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]

0.1 mg

345 USD