antibody

ZBP1 Antibody

MBS150830

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

ZBP1 Antibody

ZBP1

ZBP1; DAI; DLM1; DLM-1; C20orf183; Z-DNA-binding protein 1; Tumor stroma and activated macrophage protein DLM-1; Z-DNA binding protein 1

Z-DNA binding protein 1, isoform CRA_b; Z-DNA-binding protein 1; Z-DNA-binding protein 1; DNA-dependent activator of IRFs; DNA-dependent activator of IFN-regulatory factors; tumor stroma and activated macrophage protein DLM-1; DNA-dependent activator of interferon regulatory factors; Z-DNA binding protein 1; Tumor stroma and activated macrophage protein DLM-1

ZBP1

ZBP1; ZBP1; DAI; DLM1; DLM-1; C20orf183; C20orf183; DLM1

ZBP1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

406

ZBP1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

ZBP1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

ZBP1 antibody can be used for the detection of ZBP1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: ZBP1 antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1. Buffer: ZBP1 Antibody is supplied in PBS containing 0.02% sodium azide.

ZBP1 Antibody: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.

119595916

EAW75510

Q9H171

38,220 Da

Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!IRF3 Mediated Activation Of Type 1 IFN Pathway 576257!!IRF3-mediated Induction Of Type I IFN Pathway 833819!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!RIP-mediated NFkB Activation Via ZBP1 Pathway 576258!!Regulation Of Innate Immune Responses To Cytosolic DNA Pathway 833823!!STING Mediated Induction Of Host Immune Responses Pathway 685548

This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

0.1 mg

345 USD