antibody

TLR4 Antibody

MBS150782

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

TLR4 Antibody

TLR4

TLR4; TOLL; CD284; TLR-4; ARMD10; Toll-like receptor 4; hToll; toll-like receptor 4

toll-like receptor 4 isoform A; Toll-like receptor 4; toll-like receptor 4; hToll; homolog of Drosophila toll; toll-like receptor 4; hToll; CD_antigen: CD284

TLR4

TLR4; TLR4; TOLL; CD284; TLR-4; ARMD10

TLR4_HUMAN

Polyclonal

IgG

Rabbit

Human

839

TLR4 Antibody is Ion exchange chromatography purified.

Liquid

1 mg/mL

TLR4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

TLR4 antibody can be used for detection of TLR4 by Western blot at 2.5 - 5 mug/mL. Antibody can also be used for immunocytochemistry starting at 2 mug/mL.

Conjugate: Unconjugated. Immunogen: TLR4 antibody was raised against a peptide corresponding to 15 amino acids near the amino-terminus of human TLR4. Buffer: TLR4 Antibody is supplied in PBS containing 0.02% sodium azide.

TLR4 Antibody: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF- B. Studies with TLR4-deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram-negative sepsis.

19924149

NP_612564

NM_138554.4

O00206

73,301 Da

Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Amoebiasis Pathway 167324!!Amoebiasis Pathway 167191!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Corticotropin-releasing Hormone Pathway 920957!!HIF-1 Signaling Pathway 695200!!Hepatitis B Pathway 694606!!IKK Complex Recruitment Mediated By RIP1 Pathway 187090

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

0.1 mg

345 USD