antibody

IKK epsilon Antibody

MBS150776

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

IKK epsilon Antibody

IKK epsilon

IKK epsilon; IKKE; IKKI; IKK-E; IKK-i; IKKE; KIAA0151; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; Inducible I kappa-B kinase; I-kappa-B kinase epsilon; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

Homo sapiens IKK epsilon mRNA, complete cds; Inhibitor of nuclear factor kappa-B kinase subunit epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKK-epsilon; I-kappa-B kinase epsilon; inducible IkappaB kinase; IKK-related kinase epsilon; inducible I kappa-B kinase; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; Inducible I kappa-B kinase; IKK-i

IKBKE

IKBKE; IKBKE; IKKE; IKKI; IKK-E; IKK-i; IKKE; IKKI; KIAA0151; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i

IKKE_HUMAN

Polyclonal

IgG

Rabbit

Human

2151

It has no cross response to IKKa, IKKb, or IKKy.

IKK epsilon Antibody is affinity chromatography purified via peptide column.

Liquid

IKK epsilon antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

IKK epsilon antibody can be used for detection of IKK epsilon by Western blot at 1 mug/mL. An 80 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: IKK epsilon antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IKK epsilon. Buffer: IKK epsilon Antibody is supplied in PBS containing 0.02% sodium azide.

IKK epsilon Antibody: Nuclear factor kappa B (NF- B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF- B mediates the expression of a great variety of genes in response to extracellular stimuli. NF- B is associated with I B proteins in the cell cytoplasm, which inhibit NF- B activity. I B is phosphorylated by I B kinase (IKK) complex that contains IKK , IKK , and IKK . A novel molecule in the IKK complex was recently identified and designated IKK /IKK-i. IKK epsilon is required for the activation of NF- B by PMA and T cell receptors but not by TNF and IL-1. IKK /IKK-i message is expressed in a variety of tissues and is inducible by TNF , IL-1, and LPS.

7288877

AF241789

Q14164

80 kDa

Activated TLR4 Signalling Pathway 106400!!Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway 187088!!Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Hepatitis B Pathway 694606!!Hepatitis C Pathway 173973!!Hepatitis C Pathway 173907!!Herpes Simplex Infection Pathway 377873!!Herpes Simplex Infection Pathway 377865!!Immune System Pathway 106386

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

0.1 mg

345 USD