catalog number :
MBS150725
products full name :
OCLN Antibody
products short name :
OCLN
products name syn :
OCLN; BLCPMG; Occludin; occludin
other names :
OCLN protein; Occludin
products gene name :
OCLN
uniprot entry name :
OCLN_HUMAN
reactivity :
Human, Mouse, Rat
purity :
OCLN Antibody is affinity chromatography purified via peptide column.
storage stability :
OCLN antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
OCLN antibody can be used for detection of OCLN by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: OCLN antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human OCLN. Buffer: OCLN Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
OCLN Antibody: Tight junctions act as a semi-permeable barrier to the transport of ions, solutes, and water and are considered to function as a fence that divides apical and basolateral domains of plasma membranes. Tight junctions coordinate a variety of signaling and trafficking molecules regulating cell differentiation, proliferation, and polarity and contain a number of junctional proteins including Occludin, Claudins, junctional adhesion molecules (JAMs), as well as multiple scaffold proteins. Occludin, the first identified component of tight junction strands, is thought function as a signal transmitter in multiple signaling pathways and can associate with multiple kinases and phosphatases such as PI3-kinase and protein phosphatases 1 and 2A. At least two isoforms of OCLN are known to exist.
ncbi mol weight :
8,175 Da
ncbi pathways :
Pathogenic Escherichia Coli Infection Pathway 672459