GFR alpha 1 Antibody | MyBioSource MBS150721 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

GFR alpha 1 Antibody

catalog :

MBS150721

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150721

products type :

Antibody

products full name :

GFR alpha 1 Antibody

products short name :

GFR alpha 1

products name syn :

GFR alpha 1; GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1; GDNF family receptor alpha-1; RET ligand 1; GDNF receptor alpha-1; GDNF family receptor alpha 1

other names :

GDNF family receptor alpha-1; GDNF family receptor alpha-1; GDNF family receptor alpha-1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha-1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha; GDNF family receptor alpha 1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1

products gene name :

GFRA1

other gene names :

GFRA1; GFRA1; GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1; GDNFRA; RETL1; TRNR1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1

uniprot entry name :

GFRA1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

465

specificity :

GFR alpha 1 antibody is predicted to not cross-react with other members of the GFR alpha family of proteins.

purity :

GFR alpha 1 Antibody is Antibody is DEAE purified.

form :

Liquid

concentration :

1 mg/mL

storage stability :

GFR alpha 1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

app notes :

GFR alpha 1 antibody can be used for detection of GFR alpha 1 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 1 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: GFR alpha 1 antibody was raised against a 14 amino acid peptide near the center of human GFR alpha 1. Buffer: GFR alpha 1 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

GFR alpha 1 Antibody: Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNAs encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 (RETL1) or TGF-beta-related neurotrophic factor receptor 1 (TrnR1) and nominated as GFR -1 recently. GFR -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFR and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.

ncbi gi num :

20141405

ncbi acc num :

P56159.2

uniprot acc num :

P56159

ncbi mol weight :

51 kDa

ncbi pathways :

Axon Guidance Pathway (105688); Developmental Biology Pathway (477129); Diurnally Regulated Genes With Circadian Orthologs Pathway (198813); NCAM Signaling For Neurite Out-growth Pathway (105689); NCAM1 Interactions Pathway (105697); Signaling Events Regulated By Ret Tyrosine Kinase Pathway (137915)

ncbi summary :

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009]

uniprot summary :

GFRA1: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, GPI anchor; Receptor, misc. Chromosomal Location of Human Ortholog: 10q26.11. Cellular Component: extrinsic to membrane; plasma membrane. Molecular Function: receptor binding; glial cell line-derived neurotrophic factor receptor activity. Biological Process: axon guidance; cell surface receptor linked signal transduction

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage