antibody

TRIM25 Antibody

MBS150653

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

TRIM25 Antibody

TRIM25

TRIM25; EFP; Z147; RNF147; ZNF147; EFP; Estrogen-responsive finger protein; tripartite motif-containing 25

E3 ubiquitin/ISG15 ligase TRIM25; E3 ubiquitin/ISG15 ligase TRIM25; E3 ubiquitin/ISG15 ligase TRIM25; RING finger protein 147; zinc finger protein-147; tripartite motif-containing 25; tripartite motif protein TRIM25; estrogen-responsive finger protein; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; zinc finger protein 147 (estrogen-responsive finger protein); tripartite motif containing 25; Estrogen-responsive finger protein; RING finger protein 147; Tripartite motif-containing protein 25; Ubiquitin/ISG15-conjugating enzyme TRIM25; Zinc finger protein 147

TRIM25

TRIM25; TRIM25; EFP; Z147; RNF147; ZNF147; EFP; RNF147; ZNF147

TRI25_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

630

TRIM25 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TRIM25 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

TRIM25 antibody can be used for detection of TRIM25 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: TRIM25 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human TRIM25. Buffer: TRIM25 Antibody is supplied in PBS containing 0.02% sodium azide.

TRIM25 Antibody: TRIM25, also known as estrogen responsive finger protein (EFP) is a member of the RING finger-B box-coiled coil family and is a downstream target of estrogen receptor a. Mice lacking this gene displayed an underdeveloped uterus and reduced estrogen responsiveness demonstrating that this protein is essential for estrogen dependent proliferation. TRIM25 expression is increased in breast carcinoma where it promotes the growth of breast tumor by functioning as an E3 ubiquitin ligase that targets the negative cell cycle checkpoint 14-3-3s. Recent reports have indicated that TRIM25 E3 ubiquitin ligase is essential for the retinoic-acid-inducible gene 1 (RIG-1) signaling pathway to elicit host antiviral innate immunity.

68160937

NP_005073

NM_005082.4

Q14258

70,973 Da

Antiviral Mechanism By IFN-stimulated Genes Pathway 530760!!Cytokine Signaling In Immune System Pathway 366171!!ISG15 Antiviral Mechanism Pathway 530761!!Immune System Pathway 106386!!Influenza A Pathway 217173!!Influenza A Pathway 217150!!Innate Immune System Pathway 106387!!Interferon Signaling Pathway 187103!!Interferon Gamma Signaling Pathway 187106!!NF-kB Activation Through FADD/RIP-1 Pathway Mediated By Caspase-8 And -10 187099

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD