antibody

TREX1 Antibody

MBS150642

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

TREX1 Antibody

TREX1

TREX1; CRV; AGS1; DRN3; HERNS; Three prime repair exonuclease 1; DNase III; three prime repair exonuclease 1

three-prime repair exonuclease 1 isoform a; Three-prime repair exonuclease 1; three-prime repair exonuclease 1; DNase III; deoxyribonuclease III; 3' repair exonuclease 1; 3'-5' exonuclease TREX1; three prime repair exonuclease 1; 3'-5' exonuclease TREX1; DNase III

TREX1

TREX1; TREX1; CRV; AGS1; DRN3; HERNS

TREX1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

369

TREX1 antibody will not cross-react with the related protein TREX2.

TREX1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TREX1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

TREX1 antibody can be used for detection of TREX1 by Western blot at 0.5 and 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: TREX1 antibody was raised against a 15 amino acid synthetic peptide near the center of human TREX1. Buffer: TREX1 Antibody is supplied in PBS containing 0.02% sodium azide.

TREX1 Antibody: Trex1 is the major human 3' to 5' exonuclease which is required for checkpoint signaling after DNA damage. It is ubiquitously expressed, binds to single stranded DNA coated with replication protein A that accumulates at sites of DNA damage and recruits the ataxia telangiectasia and Rad3 related protein (ATR), a checkpoint kinase, to sites of DNA damage and replication stress. Trex1 is required for ATR expression. This gene uses two different open reading frames. The upstream ORF encodes proteins which interact with ATR and localize to intranuclear foci induced by DNA damage and are essential components of the DNA damage checkpoint. The downstream ORF encodes proteins with 3' to 5' exonuclease activity and may be a subunit of human DNA polymerase III. Multiple transcript variants encoding different isoforms have been found. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis.

7705353

NP_057465

NM_016381.5

Q9NSU2

33,212 Da

Activation Of ATR In Response To Replication Stress Pathway 105754!!Cell Cycle Pathway 530733!!Cell Cycle Checkpoints Pathway 105739!!Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!G2/M Checkpoints Pathway 105750!!G2/M DNA Damage Checkpoint Pathway 105751!!IRF3-mediated Induction Of Type I IFN Pathway 833819!!Immune System Pathway 106386

This gene encodes a nuclear protein with 3' exonuclease activity. The encoded protein may play a role in DNA repair and serve as a proofreading function for DNA polymerase. Mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, Cree encephalitis, and other diseases of the immune system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

0.1 mg

345 USD