antibody

AATF Antibody

MBS150631

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

AATF Antibody

AATF

DED; BFR2; CHE1; CHE-1; DED; HSPC277; Protein AATF; Apoptosis-antagonizing transcription factor; apoptosis antagonizing transcription factor

protein AATF; Protein AATF; protein AATF; rb-binding protein Che-1; apoptosis-antagonizing transcription factor; apoptosis antagonizing transcription factor; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1

AATF

AATF; AATF; DED; BFR2; CHE1; CHE-1; CHE1; DED

AATF_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

560

AATF Antibody is immunoaffinity purified IgG.

Liquid

1 mg/mL

AATF antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

AATF antibody can be used for the detection of AATF by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: AATF antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus of human AATF. Buffer: AATF Antibody is supplied in PBS containing 0.02% sodium azide.

AATF Antibody: AATF (apoptosis antagonizing transcription factor) was initially discovered as an interaction partner of ZIP kinase (ZIPK), a member of death-associated protein (DAP) kinase family of pro-apoptotic serine/threonine kinases. AATF is a phosphoprotein containing an acidic region and a putative leucine zipper domain and nuclear localization signal, features which are typical of transcription factors. AATF inhibits the ZIPK-mediated pro-apoptotic pathway and may activate other anti-apoptotic pathways. Recently, it has also been shown to protect neural cells against oxidative damage induced by amyloid b-peptide and to inhibit aberrant production of the beta-peptide by interacting with Par-4 (prostate apoptosis response-4), another pro-apoptotic leucine zipper protein that is associated with neuronal degeneration in Alzheimer's disease (AD), suggesting that AATF may have potential therapeutic applications in both familial and sporadic forms of AD.

7657013

NP_036270

NM_012138.3

Q9NY61

63,133 Da

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway 106443!!NRAGE Signals Death Through JNK Pathway 106444!!Regulation Of Retinoblastoma Protein Pathway 137916!!Signal Transduction Pathway 477114!!Signalling By NGF Pathway 106439!!P75 NTR Receptor-mediated Signalling Pathway 106441

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD