JMJD3 Antibody | MyBioSource MBS150629 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

JMJD3 Antibody

catalog :

MBS150629

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150629

products type :

Antibody

products full name :

JMJD3 Antibody

products short name :

JMJD3

products name syn :

JMJD3; JMJD3; JMJD3; KIAA0346; Lysine-specific demethylase 6B; JmjC domain-containing protein 3; lysine (K)-specific demethylase 6B

other names :

lysine-specific demethylase 6B; Lysine-specific demethylase 6B; lysine-specific demethylase 6B; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase; lysine (K)-specific demethylase 6B; JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B

products gene name :

KDM6B

other gene names :

KDM6B; KDM6B; JMJD3; JMJD3; KIAA0346

uniprot entry name :

KDM6B_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1682

specificity :

This antibody is specific for JMJD3 and will not recognize other JMJD proteins.

purity :

JMJD3 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

JMJD3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

JMJD3 antibody can be used for detection of EPAC1 by Western blot at 0.5 ug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 ug/mL. For immunofluorescence start at 5 ug/mL. Optimal dilutions for each application to be determined by the researcher.

other info1 :

Conjugate: Unconjugated. Immunogen: JMJD3 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human JMJD3. Buffer: JMJD3 Antibody is supplied in PBS containing 0.02% sodium azide.

other info2 :

Predicted: 167, 181 kDa. Observed: 180kDa

products description :

JMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.

ncbi gi num :

122937251

ncbi acc num :

EAW90126

ncbi gb acc num :

NM_001080424.1

uniprot acc num :

O15054

ncbi pathways :

Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); Chromatin Modifying Enzymes Pathway (1127682); Chromatin Organization Pathway (1127681); HDMs Demethylate Histones Pathway (1127685); Oxidative Stress Induced Senescence Pathway (905993)

uniprot summary :

JMJD3: Histone demethylase that specifically demethylates Lys- 27 of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 Lys-27 . Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Interacts with TLE1. Component of the MLL4 complex, at least composed of MLL4, ASH2L, RBBP5, WDR5, and KDM6B. By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Belongs to the UTX family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 1.14.11.-; Oxidoreductase. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein binding; dioxygenase activity; sequence-specific DNA binding; metal ion binding; beta-catenin binding. Biological Process: endothelial cell differentiation; establishment and/or maintenance of chromatin architecture; mesodermal cell differentiation; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; cardiac muscle cell differentiation

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage