antibody

SATB2 Antibody

MBS150603

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

SATB2 Antibody

SATB2

SATB2; KIAA1034; DNA-binding protein SATB2; Special AT-rich sequence-binding protein 2; SATB homeobox 2

DNA-binding protein SATB2; DNA-binding protein SATB2; DNA-binding protein SATB2; SATB family member 2; special AT-rich sequence-binding protein 2; SATB homeobox 2; Special AT-rich sequence-binding protein 2

SATB2

SATB2; SATB2; GLSS; KIAA1034

SATB2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

733

At least two isoforms of SATB2 are known to exist. This SATB2 antibody will not cross-react with SATB1.

SATB2 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

SATB2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

SATB2 antibody can be used for detection of SATB2 by Western blot at 2 - 4 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: SATB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human SATB2. Buffer: SATB2 Antibody is supplied in PBS containing 0.02% sodium azide.

SATB2 Antibody: Human special AT-rich sequence-binding protein-2 (SATB2) is a nuclear matrix/scaffold-associated region DNA-binding protein. Like its homolog SATB1, SATB2 selectively binds double-stranded, special AT-rich DNA sequences, but is expressed primarily in a subset of postmitotic, differentiating neurons in the neocortex. Mice deficient in SATB exhibit craniofacial abnormalities and defects in osteoblast differentiation and function. SATB2 also interacts with and enhances the activity of Runx2 and ATF4, two transcription factors that regulate osteoblast differentiation, indicating that SATB2 acts as a molecular node in a transcriptional network regulating skeletal development and osteoblast differentiation. Recent experiments have shown that SATB2 interacts with histone deacetylase 1 and metastasis-associated protein 2, two proteins that are involved in chromatin remodeling, suggesting that SATB2 may also be involved in mediating epigenetic influences during cortical development.

13634020

Q9UPW6.2

Q9UPW6

69,137 Da

This gene encodes a DNA binding protein that specifically binds nuclear matrix attachment regions. The encoded protein is involved in transcription regulation and chromatin remodeling. Defects in this gene are associated with isolated cleft palate and mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Feb 2010]

0.1 mg

345 USD