antibody

LXR-A Antibody

MBS150555

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

LXR-A Antibody

LXR-A

LXR-A; LXRA; LXR-a; RLD-1; LXRA; Oxysterols receptor LXR-alpha; Liver X receptor alpha; nuclear receptor subfamily 1, group H, member 3

oxysterols receptor LXR-alpha isoform 1; Oxysterols receptor LXR-alpha; oxysterols receptor LXR-alpha; liver X nuclear receptor alpha variant 1; nuclear receptor subfamily 1, group H, member 3; Liver X receptor alpha; Nuclear receptor subfamily 1 group H member 3

NR1H3

NR1H3; NR1H3; LXRA; LXR-a; RLD-1; LXRA

NR1H3_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

447

LXR-A Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

LXR-A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

LXR-A antibody can be used for detection of LXR-A by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: LXR-A antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus human LXR-A. Buffer: LXR-A Antibody is supplied in PBS containing 0.02% sodium azide.

LXR-A Antibody: LXR-A belongs to the Liver X Receptor family that encodes highly homologous transcription factors. Like the highly homologous LXR-B, LXR-A forms heterodimers with the retinoic acid receptor RXRalpha, function as sensors for cellular oxysterols which when activated, increase the expression of genes that control sterol and fatty acid metabolism and homeostasis. Recent experiments have indicated that the LXRs can also modulate both innate and adaptive immune responses. Human and mouse tumors produce LXR ligands that inhibit CCR7 expression on maturing dendritic cells (DCs), thereby allowing tumor immunoescape. In mouse models, it was shown that ablating LXR-A signaling led to an immune-mediated strong inhibition of tumor growth, suggesting that manipulation of this pathway may be a viable anti-cancer approach.

194294517

NP_005684

NM_005693.3

Q13133

Predicted: 44; 49 kDa. Observed: 46 kDa

Adipogenesis Pathway 198832!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Hepatitis C Pathway 173973!!Hepatitis C Pathway 173907!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862188!!Non-alcoholic Fatty Liver Disease (NAFLD) Pathway 862314!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!Nuclear Receptors In Lipid Metabolism And Toxicity Pathway 198887

The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

0.1 mg

345 USD