antibody

TOM70 Antibody

MBS150544

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

TOM70 Antibody

TOM70

TOM70; KIAA0719; TOM70; Mitochondrial import receptor subunit TOM70; Mitochondrial precursor proteins import receptor; translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)

mitochondrial import receptor subunit TOM70; Mitochondrial import receptor subunit TOM70; mitochondrial import receptor subunit TOM70; translocase of outer membrane 70 kDa subunit; mitochondrial precursor proteins import receptor; translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); Mitochondrial precursor proteins import receptor; Translocase of outer membrane 70 kDa subunit

TOMM70A

TOMM70A; TOMM70A; KIAA0719; TOM70

TOM70_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

608

TOM70 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TOM70 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

TOM70 antibody can be used for detection of TOM70 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: TOM70 antibody was raised against a 15 amino acid synthetic peptide near the center of human TOM70. Buffer: TOM70 Antibody is supplied in PBS containing 0.02% sodium azide.

TOM70 Antibody: The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. TOM70, an important member of the TOM complex, contains a tetratricopeptide repeat domain similar to those found in cytosolic chaperones such as Hsp90 and Hsc70 and provides a docking site for these proteins. This interaction is thought to be a critical first step in the TOM70-dependent mitochondrial import, followed by contact between the preprotein and TOM70. After targeting to TOM70, preproteins are translocated through the outer membrane via the TOM40 import pore complex. The precise mechanism of how preproteins progress from TOM70 to TOM40 to full translocation is still unclear. At least two isoforms of TOM70 are known to exist.

54607135

NP_055635

NM_014820.4

O94826

67,455 Da

Metabolism Of Proteins Pathway (106230); Mitochondrial Protein Import Pathway (576261)

This gene encodes an import receptor of the outer mitochondrial membrane that is part of the translocase of the outer membrane complex. This protein is involved in the import of mitochondrial precursor proteins. [provided by RefSeq, Oct 2011]

TOMM70A: Receptor that accelerates the import of all mitochondrial precursor proteins. Belongs to the Tom70 family. Protein type: Receptor, protein translocating; Mitochondrial; Membrane protein, integral. Chromosomal Location of Human Ortholog: 3q12.2. Cellular Component: mitochondrial outer membrane translocase complex; mitochondrion; membrane; integral to membrane. Molecular Function: protein binding; protein transmembrane transporter activity. Biological Process: cellular protein metabolic process; protein targeting to mitochondrion

0.1 mg

345 USD