antibody

NADE Antibody

MBS150522

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

NADE Antibody

NADE

NADE; Bex; BEX3; NADE; HGR74; DXS6984E; Protein BEX3; Brain-expressed X-linked protein 3; nerve growth factor receptor (TNFRSF16) associated protein 1

protein BEX3 isoform b; Protein BEX3; protein BEX3; brain-expressed X-linked protein 3; p75NTR-associated cell death executor; ovarian granulosa cell 13.0 kDa protein HGR74; nerve growth factor receptor (TNFRSF16) associated protein 1; Brain-expressed X-linked protein 3; Nerve growth factor receptor-associated protein 1; Ovarian granulosa cell 13.0 kDa protein HGR74; p75NTR-associated cell death executor

NGFRAP1

NGFRAP1; NGFRAP1; Bex; BEX3; NADE; HGR74; DXS6984E; BEX3; DXS6984E; NADE

BEX3_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

111

NADE Antibody is Ion exchange chromatography purified.

Liquid

1 mg/mL

NADE antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

NADE antibody can be used for detection of NADE by Western blot at 1 mug/mL. Despite its predicted molecular weight, NADE migrates at ~23 kDa in SDS-PAGE. Antibody can also be used for immunohistochemistry starting at 2 mug/mL.

Conjugate: Unconjugated. Immunogen: NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE. Buffer: NADE Antibody is supplied in PBS containing 0.02% sodium azide.

NADE Antibody: The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage.

46094060

NP_996798

NM_206915.2

Q00994

11,762 Da

Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (106443); NADE Modulates Death Signalling Pathway (106446); Neurotrophin Signaling Pathway (101143); Neurotrophin Signaling Pathway (100064); Signal Transduction Pathway (477114); Signalling By NGF Pathway (106439); P75 NTR Receptor-mediated Signalling Pathway (106441); P75(NTR)-mediated Signaling Pathway (138019)

NGFRAP1: May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. May play an important role in the pathogenesis of neurogenetic diseases. Belongs to the BEX family. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: Xq22.2. Cellular Component: cytoplasm; cytosol; nucleus. Molecular Function: protein binding; metal ion binding; death receptor binding; caspase activator activity. Biological Process: caspase activation; nerve growth factor receptor signaling pathway; induction of apoptosis via death domain receptors; multicellular organismal development; regulation of caspase activity

0.1 mg

345 USD