antibody

IRAK-M Antibody

MBS150500

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

IRAK-M Antibody

IRAK-M

IRAK-M; ASRT5; IRAKM; Interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK-3; interleukin-1 receptor-associated kinase 3

Homo sapiens IL-1 receptor-associated-kinase-M mRNA, complete cds; Interleukin-1 receptor-associated kinase 3; interleukin-1 receptor-associated kinase 3; IRAK3; IL-1 receptor-associated kinase M; interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK-M

IRAK3

IRAK3; IRAK3; ASRT5; IRAKM; IRAK-3; IRAK-M

IRAK3_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

2288

IRAK-M antibody has no cross response to IRAK or IRAK2.

IRAK-M Antibody is affinity chromatography purified via peptide column.

Liquid

IRAK-M antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

IRAK-M antibody can be used for detection of IRAK-M by Western blot at 1 mug/mL. A 68 kDa major band can be detected. IRAK-M antibody can also detect IRAK-M by immunohistochemistry at 2 mug/mL. For immunofluorescence start at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M. Buffer: IRAK-M Antibody is supplied in PBS containing 0.02% sodium azide.

IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.

5225377

AF113136

Q9Y616

68 kDa

Activated TLR4 Signalling Pathway 106400!!Apoptosis Pathway 83060!!Apoptosis Pathway 470!!Cytokine Signaling In Immune System Pathway 366171!!IL1-mediated Signaling Events Pathway 137944!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Interleukin-1 Signaling Pathway 160141!!MyD88:Mal Cascade Initiated On Plasma Membrane Pathway 106390!!Neurotrophin Signaling Pathway 101143

This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

0.1 mg

345 USD