antibody

S1P1 Antibody

MBS150494

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

S1P1 Antibody

S1P1

S1P1; EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362; EDG1; Sphingosine 1-phosphate receptor 1; Endothelial differentiation G-protein coupled receptor 1; S1P receptor 1; sphingosine-1-phosphate receptor 1

sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor 1; sphingosine 1-phosphate receptor 1; S1P receptor 1; S1P receptor Edg-1; sphingosine 1-phosphate receptor EDG1; sphingosine 1-phosphate receptor Edg-1; endothelial differentiation G-protein coupled receptor 1; endothelial differentiation, sphingolipid G-protein-coupled receptor, 1; sphingosine-1-phosphate receptor 1; Endothelial differentiation G-protein coupled receptor 1; Sphingosine 1-phosphate receptor Edg-1; S1P receptor Edg-1; CD_antigen: CD363

S1PR1

S1PR1; S1PR1; EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362; CHEDG1; EDG1; S1P receptor 1; S1P1; S1P receptor Edg-1

S1PR1_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

382

At least two isoforms of S1P1 are known to exist; this S1P1 antibody will only recognize the shorter isoform.

S1P1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

S1P1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

S1P1 antibody can be used for detection of S1P1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Conjugate: Unconjugated. Immunogen: S1P1 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human S1P1. Buffer: S1P1 Antibody is supplied in PBS containing 0.02% sodium azide.

S1P1 Antibody: Movement of lymphocytes through lymphoid organs is required for generating immunity. Their migration into lymph nodes follows a series of events including integrin activation through chemokine signaling, adhesion and diapedis. The release of lymphocytes from lymph nodes is regulated by the phospholipid sphingosine-1-phosphate (S1P). One of its receptors S1P1 binds S1P with high specificity and affinity; agonism of this receptor by the immunosuppressive agent FTY720 inhibits the entry of tissue T cells into afferent lymphatics in homeostatic and inflammatory conditions. Recent experiments have indicated that CCR7-deficient T cells left lymph nodes more rapidly than wild-type cells did and these cells where also less effectively retained after treatment with FTY720, and that egress competence could be restored by inactivating G alpha i-protein-coupled receptor signaling. These results suggest that S1P1 acts in the lymphocyte to promote lymph node egress by overcoming retention signals mediated by CCR7 and G alpha i-protein-coupled receptor signaling.

13027636

NP_001391

NM_001400.4

P21453

42,811 Da

Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!Fc-epsilon Receptor I Signaling In Mast Cells Pathway 138050!!FoxO Signaling Pathway 921162!!G Alpha (i) Signalling Events Pathway 119550!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!GPCRs, Other Pathway 198765!!Lysosphingolipid And LPA Receptors Pathway 106376

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD