Cathelicidin Antibody | MyBioSource MBS150489 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Cathelicidin Antibody

catalog :

MBS150489

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150489

products type :

Antibody

products full name :

Cathelicidin Antibody

products short name :

Cathelicidin

products name syn :

Cathelicidin; LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39; Cathelicidin antimicrobial peptide; 18 kDa cationic antimicrobial protein; cathelicidin antimicrobial peptide

other names :

cathelicidin antimicrobial peptide; Cathelicidin antimicrobial peptide; cathelicidin antimicrobial peptide; 18 kDa cationic antimicrobial protein; cathelicidin antimicrobial peptide; 18 kDa cationic antimicrobial protein; CAP-18; hCAP-18

products gene name :

CAMP

other gene names :

CAMP; CAMP; LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39; CAP18; FALL39; CAP-18; hCAP-18

uniprot entry name :

CAMP_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

170

purity :

Cathelicidin Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

Cathelicidin antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Cathelicidin antibody can be used for detection of Cathelicidin by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: Cathelicidin antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Cathelicidin. Buffer: Cathelicidin Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

Cathelicidin Antibody: One component of host defense at mucosal surfaces is epithelial-derived antimicrobial peptides. Cathelicidins are one family of antimicrobial peptides characterized by conserved pro-peptide sequences that have been identified in epithelial tissues and some myeloid cells of humans and animals. LL-37/hCAP-18 is the only Cathelicidin found in humans and is expressed in inflammatory and epithelial cells. The presence of these molecules is essential for defense against invasive bacterial infection in skin. Besides their direct antimicrobial function, Cathelicidins have multiple roles in mediating innate and adaptive immunity, such as endotoxin neutralizing, angiogenesis, wound healing and promoting neutrophil chemotaxis and mast cell recruitment. Finally, Cathelicidin antimicrobial peptides qualify as prototypes of innovative drugs that may be used to treat infection and/or modulate the immune response.

ncbi gi num :

39753970

ncbi acc num :

NP_004336

ncbi gb acc num :

NM_004345.3

uniprot acc num :

P49913

ncbi mol weight :

Predicted: 19 kDa. Observed: 18 kDa

ncbi pathways :

Disease Pathway (530764); Integrated Pancreatic Cancer Pathway (711360); Latent Infection Of Homo Sapiens With Mycobacterium Tuberculosis Pathway (645267); Phagosomal Maturation (early Endosomal Stage) Pathway (645268); SREBP Signalling Pathway (219802); Salivary Secretion Pathway (153376); Salivary Secretion Pathway (153352); Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)

ncbi summary :

This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]

uniprot summary :

CAMP: Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. Belongs to the cathelicidin family. Protein type: Secreted, signal peptide; Cell cycle regulation; Vesicle; Secreted. Chromosomal Location of Human Ortholog: 3p21.3. Cellular Component: extracellular space; specific granule; cell projection; cell wall; cytosol. Molecular Function: protein binding. Biological Process: interaction with host; positive regulation of angiogenesis; defense response to Gram-positive bacterium; innate immune response in mucosa; killing by host of symbiont cells; defense response to bacterium; positive regulation of cell proliferation; antibacterial humoral response; positive regulation of protein amino acid phosphorylation; defense response to Gram-negative bacterium

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage