STAU1 Antibody | MyBioSource MBS150484 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

STAU1 Antibody

catalog :

MBS150484

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150484

products type :

Antibody

products full name :

STAU1 Antibody

products short name :

STAU1

products name syn :

STAU1; STAU; STAU; Double-stranded RNA-binding protein Staufen homolog 1; staufen, RNA binding protein, homolog 1 (Drosophila)

other names :

double-stranded RNA-binding protein Staufen homolog 1 isoform b; Double-stranded RNA-binding protein Staufen homolog 1; double-stranded RNA-binding protein Staufen homolog 1; staufen, RNA binding protein, homolog 1; protein phosphatase 1, regulatory subunit 150; staufen double-stranded RNA binding protein 1

products gene name :

STAU1

other gene names :

STAU1; STAU1; STAU; PPP1R150; STAU

uniprot entry name :

STAU1_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

577

purity :

STAU1 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

STAU1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

STAU1 antibody can be used for detection of STAU1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 10 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: STAU1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human STAU1. Buffer: STAU1 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

STAU1 Antibody: STAU1 is a member of a family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human STAU1 also contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. STAU1 has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER. STAU1 is also known to interact with influenza ribonucleoproteins NS1, NP, and PA and is required for efficient viral replication.

ncbi gi num :

82659087

ncbi acc num :

NP_059347

ncbi gb acc num :

NM_017453.2

uniprot acc num :

O95793

ncbi mol weight :

55,635 Da

ncbi summary :

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]

uniprot summary :

STAU: Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. 3 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 20q13.1. Cellular Component: microtubule associated complex; rough endoplasmic reticulum; membrane; cell soma; endoplasmic reticulum; stress granule; dendrite; cytoplasm. Molecular Function: protein binding; double-stranded RNA binding; protein phosphatase 1 binding. Biological Process: intracellular mRNA localization; positive regulation of viral genome replication; positive regulation of viral protein levels in host cell

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage