antibody

SOX2 Antibody

MBS150482

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

SOX2 Antibody

SOX2

SOX2; ANOP3; MCOPS3; Transcription factor SOX-2; SRY (sex determining region Y)-box 2

transcription factor SOX-2; Transcription factor SOX-2; transcription factor SOX-2; transcription factor SOX2; SRY-related HMG-box gene 2; SRY (sex determining region Y)-box 2

SOX2

SOX2; SOX2; ANOP3; MCOPS3

SOX2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

317

SOX2 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

SOX2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

SOX2 antibody can be used for detection of SOX2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: SOX2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SOX. Buffer: SOX2 Antibody is supplied in PBS containing 0.02% sodium azide.

SOX2 Antibody: SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. SOX2 is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. The role of SOX2 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing SOX2 and the transcription factors POU5F1, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. Other experiments have shown that iPS cells could be generated using expression plasmids expressing POU5F1, SOX2, KlfF4 and c-Myc, eliminating the need for virus introduction.

28195386

NP_003097

NM_003106.3

P48431

34,310 Da

Cardiac Progenitor Differentiation Pathway 712094!!Developmental Biology Pathway 477129!!Hippo Signaling Pathway 749777!!Hippo Signaling Pathway 750388!!POU5F1 (OCT4), SOX2, NANOG Activate Genes Related To Proliferation Pathway 1127697!!POU5F1 (OCT4), SOX2, NANOG Repress Genes Related To Differentiation Pathway 1127698!!SIDS Susceptibility Pathways 198901!!Signaling Pathways Regulating Pluripotency Of Stem Cells 1026136!!Signaling Pathways Regulating Pluripotency Of Stem Cells 1033502!!Transcriptional Regulation Of Pluripotent Stem Cells Pathway 1127696

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

0.1 mg

345 USD