LAMP-2 Antibody | MyBioSource MBS150455 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

LAMP-2 Antibody

catalog :

MBS150455

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150455

products type :

Antibody

products full name :

LAMP-2 Antibody

products short name :

LAMP-2

products name syn :

LAMP-2; Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c; Lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B; LAMP-2; lysosomal-associated membrane protein 2

other names :

lysosome-associated membrane glycoprotein 2 isoform 2; Lysosome-associated membrane glycoprotein 2; lysosome-associated membrane glycoprotein 2; lysosomal membrane glycoprotein 2; CD107 antigen-like family member B; lysosomal membrane glycoprotein type B; lysosomal-associated membrane protein 2; CD107 antigen-like family member B; Lysosomal membrane glycoprotein type B; LGP-B; CD_antigen: CD107b

products gene name :

Lamp2

other gene names :

Lamp2; Lamp2; Mac3; LGP-B; CD107b; Lamp-2; Lamp II; Lamp-2a; Lamp-2b; Lamp-2c; Lamp-2; LAMP-2; Lysosome-associated membrane protein 2; LGP-B

uniprot entry name :

LAMP2_MOUSE

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

415

purity :

LAMP-2 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

LAMP-2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

app notes :

LAMP-2 antibody can be used for the detection of LAMP-2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: LAMP-2 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human LAMP-2. Buffer: LAMP-2 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

LAMP-2 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.

ncbi gi num :

31543108

ncbi acc num :

NP_054701

ncbi gb acc num :

NM_010685.4

uniprot acc num :

P17047

ncbi mol weight :

45,655 Da

ncbi pathways :

Hemostasis Pathway (1110026); Lysosome Pathway (99272); Lysosome Pathway (96865); Phagosome Pathway (153914); Phagosome Pathway (153859); Platelet Activation, Signaling And Aggregation Pathway (1110036); Platelet Degranulation Pathway (1110053); Response To Elevated Platelet Cytosolic Ca2+ Pathway (1110051); Senescence And Autophagy Pathway (198361); Tuberculosis Pathway (213781)

uniprot summary :

LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Cellular Component: phagocytic vesicle membrane; membrane; lysosome; late endosome membrane; lysosomal membrane; late endosome; integral to membrane; plasma membrane; platelet dense granule membrane; endosome. Molecular Function: protein domain specific binding; enzyme binding. Biological Process: protein stabilization

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage