KIF5 Antibody | MyBioSource MBS150427 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

KIF5 Antibody

catalog :

MBS150427

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150427

products type :

Antibody

products full name :

KIF5 Antibody

products short name :

KIF5

products name syn :

KIF5; NKHC; MY050; SPG10; D12S1889; NKHC1; Kinesin heavy chain isoform 5A; Kinesin heavy chain neuron-specific 1; NKHC; kinesin family member 5A

other names :

Kinesin heavy chain isoform 5A; Kinesin heavy chain isoform 5A; kinesin heavy chain isoform 5A; KIF5A variant protein; neuronal kinesin heavy chain; kinesin heavy chain neuron-specific 1; kinesin, heavy chain, neuron-specific; kinesin family member 5A; Kinesin heavy chain neuron-specific 1; Neuronal kinesin heavy chain; NKHC

products gene name :

KIF5A

other gene names :

KIF5A; KIF5A; NKHC; MY050; SPG10; D12S1889; NKHC1; NKHC

uniprot entry name :

KIF5A_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1032

purity :

KIF5 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

KIF5 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

KIF5 antibody can be used for detection of KIF5 by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: KIF5 antibody was raised against a 20 amino acid synthetic peptide from near the center of human KIF5. Buffer: KIF5 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

KIF5 Antibody: The kinesin superfamily proteins (KIFs) are microtubule-dependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. KIF5 has at least three known isoforms; this antibody recognizes all three. Mutations in one of the isoforms of KIF5 (KIF5A) are thought to be involved in hereditary spastic paraplegias.

ncbi gi num :

143811412

ncbi acc num :

Q12840.2

uniprot acc num :

Q12840

ncbi mol weight :

117,378 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Dopaminergic Synapse Pathway (469199); Dopaminergic Synapse Pathway (469185); Factors Involved In Megakaryocyte Development And Platelet Production Pathway (187196); Hemostasis Pathway (106028); Immune System Pathway (106386); Insulin Processing Pathway (105903); Kinesins Pathway (187197); MHC Class II Antigen Presentation Pathway (645290); Metabolism Of Proteins Pathway (106230)

ncbi summary :

This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10. [provided by RefSeq, Jul 2008]

uniprot summary :

KIF5A: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10 (SPG10). An inherited degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Belongs to the kinesin-like protein family. Kinesin subfamily. Protein type: Motor; Microtubule-binding. Chromosomal Location of Human Ortholog: 12q13.13. Cellular Component: kinesin complex; microtubule; membrane; perinuclear region of cytoplasm; cytosol. Molecular Function: protein binding; plus-end-directed microtubule motor activity; microtubule binding; ATPase activity; motor activity; ATP binding. Biological Process: synaptic transmission; axon guidance; protein localization; metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class II; cytoskeleton-dependent intracellular transport; blood coagulation; microtubule-based movement. Disease: Spastic Paraplegia 10, Autosomal Dominant

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage