catalog number :
MBS150424
products full name :
RIP3 Antibody
products short name :
RIP3
products name syn :
RIP3; Rip3; AW107945; 2610528K09Rik; Rip3; RIP-like protein kinase 3; RIP-3; receptor-interacting serine-threonine kinase 3
other names :
receptor interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; receptor-interacting serine/threonine-protein kinase 3; RIP-3; mRIP3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting protein 3; receptor-interacting serine-threonine kinase 3; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; mRIP3
products gene name :
Ripk3
other gene names :
Ripk3; Ripk3; Rip3; AW107945; 2610528K09Rik; Rip3; RIP-3; mRIP3
uniprot entry name :
RIPK3_MOUSE
purity :
RIP3 Antibody is affinity chromatography purified via peptide column.
storage stability :
RIP3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
RIP3 antibody can be used for detection of RIP3 by Western blot at 1 mug/mL. An approximately 57 kDa band can be detected. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: RIP3 antibody was raised against a 14 amino acid peptide near the carboxy terminus of murine RIP3. Buffer: RIP3 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
RIP3 Antibody: Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF- B activation. Overexpression of RIP3 induces apoptosis and NF- B activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
ncbi pathways :
Activated TLR4 Signalling Pathway 1110727!!Cytosolic DNA-sensing Pathway 125146!!Cytosolic DNA-sensing Pathway 124833!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 1110756!!IKK Complex Recruitment Mediated By RIP1 Pathway 1110714!!Immune System Pathway 1110668!!Innate Immune System Pathway 1110697!!MyD88-independent Cascade Pathway 1110711!!RIP-mediated NFkB Activation Via ZBP1 Pathway 1110759!!TNF Signaling Pathway 812263