antibody

TLR6 Antibody

MBS150419

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

TLR6 Antibody

TLR6

TLR6; CD286; Toll-like receptor 6; toll-like receptor 6

toll-like receptor 6; Toll-like receptor 6; toll-like receptor 6; toll-like receptor 6; CD_antigen: CD286

TLR6

TLR6; TLR6; CD286

TLR6_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

796

TLR6 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

TLR6 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC)

TLR6 antibody can be used for detection of TLR6 by Western blot at 0.5 to 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 10 mug/mL.

Conjugate: Unconjugated. Immunogen: TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6. Buffer: TLR6 Antibody is supplied in PBS containing 0.02% sodium azide.

TLR6 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify. Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan. Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses.

20143971

NP_006059

NM_006068.4

Q9Y2C9

55,828 Da

Activated TLR4 Signalling Pathway 106400!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!MyD88:Mal Cascade Initiated On Plasma Membrane Pathway 106390!!Phagosome Pathway 153910!!Phagosome Pathway 153859!!Regulation Of Toll-like Receptor Signaling Pathway 920955!!Toll Like Receptor 2 (TLR2) Cascade Pathway 106402

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor functionally interacts with toll-like receptor 2 to mediate cellular response to bacterial lipoproteins. A Ser249Pro polymorphism in the extracellular domain of the encoded protein may be associated with an increased of asthma is some populations.[provided by RefSeq, Jan 2011]

0.1 mg

345 USD