catalog number :
MBS150400
products full name :
NCLN Antibody
products short name :
NCLN
products name syn :
NCLN; NET59; Nicalin; Nicastrin-like protein; nicalin
other names :
nicalin; Nicalin; nicalin; nicastrin-like protein; nicalin homolog (zebrefish); nicalin; Nicastrin-like protein
products gene name :
NCLN
other gene names :
NCLN; NCLN; NET59
uniprot entry name :
NCLN_HUMAN
reactivity :
Human, Mouse, Rat
purity :
NCLN Antibody is affinity chromatography purified via peptide column.
storage stability :
NCLN antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
NCLN antibody can be used for detection of NCLN by Western blot at 0.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 2.5 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: NCLN antibody was raised against an 18 amino acid synthetic peptide near the carboxy terminus of human NCLN. Buffer: NCLN Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
NCLN Antibody: Nicalin, along with its binding partner Nomo, is a novel signaling antagonist to Nodals, signaling factors of the TGF- superfamily that play a key role in vertebrate development. Nicalin is distantly related to Nicastrin, a component of the Alzheimer's disease-associated gamma-secretase, and is thought to have a similar function. Another protein, TMEM147, has also been recently identified as associating with Nicalin and NOMO as part of the gamma-secretase-like complex.
ncbi gb acc num :
NM_020170.3
ncbi mol weight :
62,846 Da