antibody

sRANK Ligand Antibody

MBS150390

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

sRANK Ligand Antibody

sRANK Ligand

sRANK Ligand; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; Tumor necrosis factor ligand superfamily member 11; Osteoclast differentiation factor; ODF; tumor necrosis factor (ligand) superfamily, member 11

tumor necrosis factor ligand superfamily member 11 isoform 1; Tumor necrosis factor ligand superfamily member 11; tumor necrosis factor ligand superfamily member 11; osteoprotegerin ligand; osteoclast differentiation factor; TNF-related activation-induced cytokine; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor (ligand) superfamily, member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD_antigen: CD254Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form

TNFSF11

TNFSF11; TNFSF11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE

TNF11_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

317

sRANK Ligand Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

sRANK Ligand antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

sRANK-L antibody can be used for detection of sRANK-L by Western blot at 0.25 - 0.5 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL.

Conjugate: Unconjugated. Immunogen: sRANK-L antibody was raised against a 14 amino acid synthetic peptide from near the center of human sRANK-L. Buffer: sRANK Ligand Antibody is supplied in PBS containing 0.02% sodium azide.

sRANK Ligand Antibody: The receptor activator of NF- B ligand (RANK-L) is a recently discovered member of the TNF-ligand family involved in the regulation of the T cell-dependent immune response, lymph node organogenesis and bone formation. RANK-L exists as both a normal, transmembrane form and a truncated, soluble form (sRANK-L), both of which can stimulate the receptor. Activation of T cells, such as by treatment with interleukin-7, induces RANK-L production and leads to an increase of osteoclast formation and bone loss. Finally, sRANK-L can activate the antiapoptotic kinase Akt through a signaling complex involving Src kinase and TRAF6, suggesting sRANK-L may also play a role in regulating apoptosis. This antibody will recognize both the soluble form and the uncleaved transmembrane form of RANK-L.

4507595

NP_003692

NM_003701.3

O14788

35 kDa

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!IL6-mediated Signaling Events Pathway 137932!!NF-kappa B Signaling Pathway 634527!!Osteoblast Signaling Pathway 198842!!Osteoclast Signaling Pathway 198769!!Osteoclast Differentiation Pathway 193147!!Osteoclast Differentiation Pathway 193096!!Prolactin Signaling Pathway 814182!!Prolactin Signaling Pathway 814248

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD