antibody

LSD1 Antibody

MBS150364

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

LSD1 Antibody

LSD1

LSD1; AOF2; KDM1; LSD1; BHC110; AOF2; KIAA0601; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; lysine (K)-specific demethylase 1

lysine-specific histone demethylase 1A isoform a; Lysine-specific histone demethylase 1A; lysine-specific histone demethylase 1A; lysine (K)-specific demethylase 1; BRAF35-HDAC complex protein BHC110; amine oxidase (flavin containing) domain 2; FAD-binding protein BRAF35-HDAC complex, 110 kDa subunit; flavin-containing amine oxidase domain-containing protein 2; lysine (K)-specific demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2

KDM1

KDM1A; KDM1A; AOF2; KDM1; LSD1; BHC110; AOF2; KDM1; KIAA0601; LSD1

KDM1A_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

876

LSD1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

LSD1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB)

LSD1 antibody can be used for the detection of LSD1 by Western blot at 1 - 2 mug/mL.

Conjugate: Unconjugated. Immunogen: LSD1 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human LSD1. Buffer: LSD1 Antibody is supplied in PBS containing 0.02% sodium azide.

LSD1 Antibody: Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction. Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription. LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulate LSD1 activity in vivo, and in a histone H3-K4-specific methylase complex that is involved in transcriptional regulation. Experiments have shown that CoREST, a SANT domain-containing corepressor acts to enhance LSD1 activity, while BHC80, a PHD domain-containing protein, inhibits CoREST/LSD1 activity in vitro. LSD1-mediated histone demethylation thus may have significant effects on gene expression.

58761544

NP_001009999

NM_001009999.2

O60341

95,155 Da

Androgen Receptor Signaling Pathway 198806!!Chromatin Modifying Enzymes Pathway 1127682!!Chromatin Organization Pathway 1127681!!Coregulation Of Androgen Receptor Activity Pathway 138085!!Factors Involved In Megakaryocyte Development And Platelet Production Pathway 187196!!HDACs Deacetylate Histones Pathway 1127684!!HDMs Demethylate Histones Pathway 1127685!!Hemostasis Pathway 106028!!Notch Signaling Pathway 169345!!Notch-mediated HES/HEY Network Pathway 169347

This gene encodes a nuclear protein containing a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. This protein is a component of several histone deacetylase complexes, though it silences genes by functioning as a histone demethylase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

0.1 mg

345 USD