antibody

EBI3 Antibody

MBS150360

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

EBI3 Antibody

EBI3

EBI3; IL27B; IL-27B; IL27B; Interleukin-27 subunit beta; Epstein-Barr virus-induced gene 3 protein; IL-27 subunit beta; Epstein-Barr virus induced 3

interleukin-27 subunit beta; Interleukin-27 subunit beta; interleukin-27 subunit beta; IL27 subunit; IL35 subunit; cytokine receptor; IL-27 subunit beta; EBV-induced gene 3 protein; Epstein-Barr virus induced gene 3; epstein-Barr virus-induced gene 3 protein; Epstein-Barr virus induced 3; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein

EBI3

EBI3; EBI3; IL27B; IL-27B; IL27B; IL-27 subunit beta; IL-27B; EBV-induced gene 3 protein

IL27B_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

229

EBI3 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

EBI3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

EBI3 antibody can be used for the detection of EBI3 by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: EBI3 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human EBI3. Buffer: EBI3 Antibody is supplied in PBS containing 0.02% sodium azide.

EBI3 Antibody: EBI3 is a subunit in two distinct heterodimeric cytokines: interleukin-27 (IL-27) and IL-35. Like interleukin-23 (IL-23), IL-27 is a recently discovered member of the IL-6/IL-12 family of proinflammatory and immunoregulatory cytokines. It exists as a heterodimer composed of the p40-related protein EBI3 and an IL-12 p35-related protein termed p28. IL-27 is produced after activation by antigen-presenting cells and induces proliferation of naïve but not memory CD4+ T-cells. It acts by binding to its receptor WSX-1 (also known as TCCR) and gp130 which results in the activation of a Jak/STAT signaling cascade, suggesting the IL-27 is involved in the regulation of immune processes. It has been suggested that IL-27 can also be used as a therapeutic agent against cancer as it can also induce tumor-specific anti-tumor activity mediated through CD8+ T-cells, IFN-gamma, and T-bet. IL-35 is composed of EBI3 and the p35 subunit of IL-12 and has been reported to have therapeutic effects against collagen-induced arthritis by expanding the population of regulatory T cells and suppressing Th17 cells. At least two isoform of EBI3 are known to exist.

14577917

NP_005746

NM_005755.2

Q14213

25,396 Da

IL27-mediated Signaling Events Pathway 137929

This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008]

0.1 mg

345 USD