antibody

TIRP Antibody

MBS150354

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

TIRP Antibody

TIRP

TIRP; TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2; TIRP; TIR domain-containing adapter molecule 2; Putative NF-kappa-B-activating protein 502; toll-like receptor adaptor molecule 2

TIR domain-containing adapter protein; TIR domain-containing adapter molecule 2; TRAM adaptor with GOLD domain; TMED7-TICAM2 read-through transcript; TMED7-TICAM2 readthrough; Putative NF-kappa-B-activating protein 502; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein; MyD88-4

TICAM2

TMED7-TICAM2; TICAM2; TIRAP3; TIRP; TRAM; TICAM-2; MyD88-4

TCAM2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

235

TIRP Antibody is Ion exchange chromatography purified.

Liquid

1 mg/mL

TIRP antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

TIRP antibody can be used for detection of TIRP by Western blot at 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: TIRP antibody was raised against a peptide corresponding to amino acids near the C-terminus of human TIRP. Buffer: TIRP Antibody is supplied in PBS containing 0.02% sodium azide.

TIRP Antibody: TIRP is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TIRP, along with other molecules such as TRIF, MAL, and MyD88, serves as an adaptor protein that allows for the interaction and activation of the IL-1R-associated kinase (IRAK) family, the subsequent activation of TNF receptor associated factor (TRAF)-6, and ultimately the activation of NF- B. Expression of TIRP appears to be essential for TLR4 signalling.

32435943

AAP81748

Q86XR7

46,173 Da

IL1-mediated Signaling Events Pathway 137944!!Toll-like Receptor Signaling Pathway 198855

This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]

0.1 mg

345 USD