catalog number :
MBS150348
products full name :
EZH1 Antibody
products short name :
EZH1
products name syn :
EZH1; KMT6B; KIAA0388; Histone-lysine N-methyltransferase EZH1; ENX-2; enhancer of zeste homolog 1
other names :
histone-lysine N-methyltransferase EZH1; Histone-lysine N-methyltransferase EZH1; histone-lysine N-methyltransferase EZH1; ENX-2; enhancer of zeste homolog 1; enhancer of zeste 1 polycomb repressive complex 2 subunit; ENX-2; Enhancer of zeste homolog 1
products gene name :
EZH1
other gene names :
EZH1; EZH1; KMT6B; KIAA0388
uniprot entry name :
EZH1_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
Multiple isoforms of EZH1 are known to exist. EZH1 antibody is predicted to not cross-react with EZH2
purity :
EZH1 Antibody is affinity chromatography purified via peptide column.
storage stability :
EZH1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
app notes :
EZH1 antibody can be used for detection of EZH1 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: EZH1 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human EZH1. Buffer: EZH1 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
EZH1 Antibody: EZH1 was initially identified as a homolog of the drosophila Enhancer of Zeste through transcription mapping of chromosome 17q21. Both EZH1 and the related protein EZH2 can form complexes with the noncanonical Polycomb repressive complex-2 (PRC2) and maintain repressive chromatin, but the PRC2-EZH1 complex mediates methylation of histone H3. Both EZH1 and EZH2 are thought to function in the maintenance of embryonic stem cell pluripotency and plasticity and recently have been shown to be essential for hair follicle homeostasis and wound repair.
ncbi gb acc num :
NM_001991.3
ncbi mol weight :
68,961 Da
ncbi summary :
EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]