product summary
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company name :
MyBioSource
product type :
antibody
product name :
Spred2 Antibody
catalog :
MBS150328
quantity :
0.1 mg
price :
345 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS150328
products type :
Antibody
products full name :
Spred2 Antibody
products short name :
Spred2
products name syn :
Spred2; Spred-2; Sprouty-related; EVH1 domain-containing protein 2; Spred-2; sprouty-related, EVH1 domain containing 2
other names :
sprouty-related, EVH1 domain-containing protein 2 isoform a; Sprouty-related, EVH1 domain-containing protein 2; sprouty-related, EVH1 domain-containing protein 2; sprouty protein with EVH-1 domain 2, related sequence; sprouty-related, EVH1 domain containing 2
products gene name :
SPRED2
other gene names :
SPRED2; SPRED2; Spred-2; Spred-2
uniprot entry name :
SPRE2_HUMAN
clonality :
Polyclonal
isotype :
IgG
host :
Rabbit
reactivity :
Human
sequence length :
418
specificity :
This Spred2 antibody is predicted to have no cross-reactivity to Spred1 or Spred3.
purity :
Spred2 Antibody is affinity chromatography purified via peptide column.
form :
Liquid
concentration :
1 mg/mL
storage stability :
Spred2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
Spred2 antibody can be used for detection of Spred2 by Western blot at 1 - 2 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: Spred2 antibody was raised against a 13 amino acid synthetic peptide near the center of the human Spred2. Buffer: Spred2 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
Spred2 Antibody: Spred2 is a member of the Sprouty family, a group of proteins that act as negative regulators during development. Like Spred1, Spred2 acts by suppressing the phosphorylation and activation of Raf. The Spred proteins have also been implicated in the negative feedback regulation of FGF signaling in embryogenesis and angiogenesis. Further studies have shown that expression levels of Spred1 and Spred2 proteins are inversely correlated with the incidence of tumor invasion and metastasis in human hepatocellular carcinoma (HHC), suggesting that these proteins could be useful as prognostic factors and therapeutic targets in HCC. At least two isoforms of Spred2 are known to exist.
ncbi gi num :
189571669
ncbi acc num :
NP_861449
ncbi gb acc num :
NM_181784.2
uniprot acc num :
Q7Z698
ncbi mol weight :
47,033 Da
ncbi pathways :
Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488); Kit Receptor Signaling Pathway (198826); Signaling Events Mediated By Stem Cell Factor Receptor (c-Kit) Pathway (138068)
ncbi summary :
SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
uniprot summary :
SPRED2: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Vesicle; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 2p14. Cellular Component: nucleoplasm; cytoplasm; plasma membrane. Molecular Function: protein serine/threonine kinase inhibitor activity; protein binding; stem cell factor receptor binding; protein kinase binding. Biological Process: multicellular organismal development; positive regulation of DNA damage response, signal transduction by p53 class mediator; inactivation of MAPK activity
size1 :
0.1 mg
price1 :
345 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."

Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...

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