catalog number :
MBS150318
products full name :
RILPL1 Antibody
products short name :
RILPL1
products name syn :
RILPL1; RLP1; GOSPEL; RLP1; RILP-like protein 1; Rab-interacting lysosomal-like protein 1; Rab interacting lysosomal protein-like 1
other names :
RILP-like protein 1; RILP-like protein 1; RILP-like protein 1; rab-interacting lysosomal-like protein 1; Rab interacting lysosomal protein-like 1; Rab-interacting lysosomal-like protein 1
products gene name :
RILPL1
other gene names :
RILPL1; RILPL1; RLP1; GOSPEL; RLP1
uniprot entry name :
RIPL1_HUMAN
reactivity :
Human, Mouse, Rat
specificity :
At least three isoforms of RILPL1 are known to exist; this antibody will detect the two shorter isoforms. RILPL1 antibody is predicted to not cross-react with RILP.
purity :
RILPL1 Antibody is affinity chromatography purified via peptide column.
storage stability :
RILPL1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
tested application :
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
app notes :
RILPL1 antibody can be used for detection of RILPL1 by Western blot at 0.5 and 1 mug/mL. Antibody can also be used for immunofluorescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.
other info1 :
Conjugate: Unconjugated. Immunogen: RILPL1 antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human RILPL1. Buffer: RILPL1 Antibody is supplied in PBS containing 0.02% sodium azide.
products description :
RILPL1 Antibody: While the function of the Rab interacting lysosomal protein-like 1 (RILPL1) remains unknown, the homologous protein RILP is a small GTPase that controls transport to endocytic compartments, suggesting RILPL1 may have similar functions. However, overexpression of RILP caused enlarged lysosomes that are more centrally located in the cell, while overexpression of RILPL1 had no visible effect on the location or morphology of lysosomes.
ncbi gb acc num :
NM_178314.3
ncbi mol weight :
29,468 Da
uniprot summary :
RILPL1: Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution. Belongs to the RILPL family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Unknown function. Chromosomal Location of Human Ortholog: 12q24.31. Cellular Component: nucleoplasm; centrosome; cytoplasm; plasma membrane; cytosol. Biological Process: intracellular protein transport