antibody

NOD3 Antibody

MBS150315

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

NOD3 Antibody

NOD3

NOD3; NOD3; CLR16.2; NOD3; Protein NLRC3; CARD15-like protein; NLR family, CARD domain containing 3

NOD3 protein, isoform CRA_d; Protein NLRC3; protein NLRC3; CARD15-like protein; NOD-like receptor C3; caterpiller protein 16.2; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 3; NLR family, CARD domain containing 3; CARD15-like protein; Caterpiller protein 16.2; CLR16.2; Nucleotide-binding oligomerization domain protein 3

NLRC3

NLRC3; NLRC3; NOD3; CLR16.2; NOD3; CLR16.2

NLRC3_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

1112

NOD3 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

NOD3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

NOD3 antibody can be used for detection of NOD3 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunofluorescence starting at 20 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3. Buffer: NOD3 Antibody is supplied in PBS containing 0.02% sodium azide.

NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.

119605757

EAW85351

Q7RTR2

111,634 Da

This gene encodes a NOD-like receptor family member. The encoded protein is a cytosolic regulator of innate immunity. This protein directly interacts with stimulator of interferon genes (STING), to prevent its proper trafficking, resulting in disruption of STING-dependent activation of the innate immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

NLRC3: May modulate T-cell activation. Decreases the transcription of genes that are normally up-regulated after T-cell stimulation. Delays degradation of NFKBIA/IKBA. Belongs to the NLRP family. 4 isoforms of the human protein are produced by alternative splicing. Chromosomal Location of Human Ortholog: 16p13.3. Cellular Component: cytoplasm. Molecular Function: ATP binding. Biological Process: I-kappaB kinase/NF-kappaB cascade; T cell activation; regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; response to lipopolysaccharide; negative regulation of I-kappaB kinase/NF-kappaB cascade

0.1 mg

345 USD