antibody

PIAS2 Antibody

MBS150305

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

PIAS2 Antibody

PIAS2

PIAS2; DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA; E3 SUMO-protein ligase PIAS2; Androgen receptor-interacting protein 3; protein inhibitor of activated STAT, 2

protein inhibitor of activated STAT, 2, isoform CRA_b; E3 SUMO-protein ligase PIAS2; E3 SUMO-protein ligase PIAS2; DAB2-interacting protein; zinc finger, MIZ-type containing 4; msx-interacting zinc finger protein; protein inhibitor of activated STAT X; androgen receptor-interacting protein 3; protein inhibitor of activated STAT, 2; Androgen receptor-interacting protein 3; ARIP3; DAB2-interacting protein; DIP; Msx-interacting zinc finger protein; Miz1; PIAS-NY protein; Protein inhibitor of activated STAT x; Protein inhibitor of activated STAT2

PIAS2

PIAS2; PIAS2; DIP; MIZ; MIZ1; SIZ2; ARIP3; PIASX; ZMIZ4; PIASX-BETA; PIASX-ALPHA; PIASX; ARIP3; DIP; Miz1

PIAS2_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

626

PIAS2 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

PIAS2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

PIAS2 antibody can be used for detection of PIAS2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: PIAS2 antibody was raised against a 18 amino acid synthetic peptide near the amino terminus of human PIAS2. Buffer: PIAS2 Antibody is supplied in PBS containing 0.02% sodium azide.

PIAS2 Antibody: The PIAS (protein inhibitor of activated STAT) proteins play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS2. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS2 binds specifically to STAT4 following IL-12 stimulation and inhibits STAT4-mediated gene activation in human T cells. PIAS2 is a potent transcriptional activator of Bcl-2, but together with Bcl-6 can suppress the expression of Bcl-2.

119621890

EAX01485

O75928

45,057 Da

IL12 Signaling Mediated By STAT4 Pathway 137936!!Jak-STAT Signaling Pathway 83077!!Jak-STAT Signaling Pathway 488!!Pathways In Cancer 83105!!Small Cell Lung Cancer Pathway 83118!!Small Cell Lung Cancer Pathway 530!!Sumoylation By RanBP2 Regulates Transcriptional Repression Pathway 138029!!TGF-beta Receptor Signaling Pathway 198774!!Ubiquitin Mediated Proteolysis Pathway 83056!!Ubiquitin Mediated Proteolysis Pathway 466

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]

0.1 mg

345 USD