antibody

FAM59A Antibody

MBS150293

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

FAM59A Antibody

FAM59A

FAM59A; Gm944; FAM59A; C18orf11; GRB2-associated and regulator of MAPK protein; GRB2-associated and regulator of MAPK1; family with sequence similarity 59, member A

GRB2-associated and regulator of MAPK protein; GRB2-associated and regulator of MAPK protein; GRB2-associated and regulator of MAPK protein; protein FAM59A; GRB2-associated and regulator of MAPK1; Grb2-associated and regulator of Erk/MAPK; family with sequence similarity 59, member A; GRB2 associated, regulator of MAPK1; GRB2-associated and regulator of MAPK1

FAM59A

GAREM; GAREM; Gm944; FAM59A; C18orf11; C18orf11; FAM59A

GAREM_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

876

FAM59A Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

FAM59A antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

FAM59A antibody can be used for detection of FAM59A by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: FAM59A antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human FAM59A. Buffer: FAM59A Antibody is supplied in PBS containing 0.02% sodium azide.

FAM59A Antibody: FAM59A, also known as GAREM, was initially identified through a mass spectroscoptic method that measures different phosphotyrosine states of proteins in response to different cell stimuli. FAM59A is a downstream molecule in the EGF signaling pathway that is tyrosine-phosphorylated, and this phosphorylation is needed for the binding of Grb2, an adaptor protein crucial to the transduction of growth signals from the plasma membrane to the nucleus. ERK activation in response to EGF stimulation is regulated by FAM59A in COS-7 and HeLa cells, and the overexpression of FAM59A stimulated cell proliferation and colony formation in soft agar, suggesting that FAM59A might be a critical protein with roles in ligand-mediated signaling pathway of the EGF receptor and the tumorigenesis of cells.

125991851

Q9H706.2

Q9H706

97,099 Da

This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

0.1 mg

345 USD