antibody

NK3R Antibody

MBS150256

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

NK3R Antibody

NK3R

NK3R; NKR; HH11; NK3R; NK-3R; TAC3RL; TAC3R; Neuromedin-K receptor; NK-3 receptor; NKR; tachykinin receptor 3

Neuromedin-K receptor; Neuromedin-K receptor; neuromedin-K receptor; NK-3 receptor; neurokinin B receptor; neurokinin beta receptor; tachykinin receptor 3; NK-3 receptor; NK-3R; Neurokinin B receptor; Tachykinin receptor 3

TACR3

TACR3; TACR3; NKR; HH11; NK3R; NK-3R; TAC3RL; NK3R; TAC3R; NKR; NK-3R

NK3R_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse

465

NK3R Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

NK3R antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

NK3R antibody can be used for detection of NK3R by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: NK3R antibody was raised against a 18 amino acid synthetic peptide from near the center of human NK3R. Buffer: NK3R Antibody is supplied in PBS containing 0.02% sodium azide.

NK3R Antibody: The tachykinins are a family of small peptides that include the neurotransmitters substance P, neurokinin A, and neurokinin B, which can act on three related but distinct seven transmembrane G-proteins coupled receptors, albeit at different concentrations. The NK-3 receptor (NK3R) has greatest affinity for neurokinin B and is highly expressed in the supraoptic and paraventricular nuclei. Following binding of its ligand, NK3R activates a phosphatidylinositol-calcium second messenger system. It is likely these signals lead to the release of vasopressin and oxytocin into the circulation. NK3R may be involved in learning and memory as mice lacking this gene expressed cognitive deficits compared to normal mice. Although it has been suggested that NK3R plays a role in the regulation of vagal afferent relay neurons, it is likely that these receptors are activated by substance P or neurokinin A, as the airway nerves do not express neurokinin B. NK3R antibody does not recognize NK1R or NK2R.

128364

P29371.1

P29371

52,202 Da

Calcium Signaling Pathway 83050!!Calcium Signaling Pathway 459!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1127664!!Disease Pathway 530764!!G Alpha (q) Signalling Events Pathway 106043!!GPCR Downstream Signaling Pathway 119548!!GPCR Ligand Binding Pathway 161020!!Gastrin-CREB Signalling Pathway Via PKC And MAPK 645295!!Metabolic Disorders Of Biological Oxidation Enzymes Pathway 1127637

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]

0.1 mg

345 USD