Emerin Antibody | MyBioSource MBS150246 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Emerin Antibody

catalog :

MBS150246

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150246

products type :

Antibody

products full name :

Emerin Antibody

products short name :

Emerin

products name syn :

Emerin; STA; EDMD; LEMD5; STA; Emerin; emerin

other names :

emerin; Emerin; emerin; LEM domain containing 5; emerin

products gene name :

EMD

other gene names :

EMD; EMD; STA; EDMD; LEMD5; EDMD; STA

uniprot entry name :

EMD_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

254

purity :

Emerin Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

Emerin antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

app notes :

Emerin antibody can be used for detection of Emerin by Western blot at 0.5 - 1 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL. For immunofluorescence start at 10 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: Emerin antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human Emerin. Buffer: Emerin Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

Emerin Antibody: Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family that includes proteins such as LAP2 and MAN1. Each family member, including Emerin, has an ~40 amino acid LEM-domains that binds barrier-to-autointegration (BANF1), a conserved chromatin protein that also serves as a host cell component of retroviral integration complexes, including that of HIV. Emerin is anchored at the inner membrane of the nuclear envelope where it binds to nuclear intermediate filaments that are formed by lamin proteins. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.

ncbi gi num :

4557553

ncbi acc num :

NP_000108

ncbi gb acc num :

NM_000117.2

uniprot acc num :

P50402

ncbi mol weight :

28,994 Da

ncbi pathways :

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765); Clearance Of Nuclear Envelope Membranes From Chromatin Pathway (771572); Depolymerisation Of The Nuclear Lamina Pathway (1127548); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229)

ncbi summary :

Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. [provided by RefSeq, Jul 2008]

uniprot summary :

emerin: a single pass membrane protein that spans the inner nuclear membrane. A serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It interacts with lamins A and C, and mediates membrane anchorage to the cytoskeleton. Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through an exportin 1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Colocalized with BAF at the central region of the assembling nuclear rim, near spindle-attachment sites. Hyper-phosphorylated on tyrosine in cells overexpressing HER2. Directly phosphorylated by Src and Abl. Phosphorylated by Src at Y59, Y74 and Y95. May function as a downstream effector and signal integrator for tyrosine kinase signaling pathways at the nuclear envelope. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene. Protein type: Cytoskeletal; Membrane protein, integral. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: microtubule; nuclear outer membrane; nuclear membrane; membrane; endoplasmic reticulum; integral to membrane; nuclear inner membrane; nuclear envelope. Molecular Function: protein binding; beta-tubulin binding; actin binding. Biological Process: positive regulation of protein export from nucleus; mitotic nuclear envelope reassembly; muscle development; muscle contraction; negative regulation of fibroblast proliferation; mitotic nuclear envelope disassembly; mitotic cell cycle. Disease: Emery-dreifuss Muscular Dystrophy 1, X-linked

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage