antibody

UNG1 Antibody

MBS150242

0.1 mg

345 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

UNG1 Antibody

UNG1

UNG1; DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15; DGU; Uracil-DNA glycosylase; uracil-DNA glycosylase

uracil-DNA glycosylase isoform UNG1; Uracil-DNA glycosylase; uracil-DNA glycosylase; UDG; UNG; uracil-DNA glycosylase 1, uracil-DNA glycosylase 2; uracil-DNA glycosylase

UNG

UNG; UNG; DGU; UDG; UNG1; UNG2; HIGM4; HIGM5; UNG15;

UNG_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

304

UNG1 Antibody is affinity chromatography purified via peptide column.

Liquid

1 mg/mL

UNG1 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

UNG1 antibody can be used for the detection of UNG1 by Western blot at 0.5 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2 mug/mL. For immunofluorescence start at 20 mug/mL.

Conjugate: Unconjugated. Immunogen: UNG1 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human UNG1. Buffer: UNG1 Antibody is supplied in PBS containing 0.02% sodium azide.

UNG1 Antibody: The human uracil-DNA glycosylase (UNG) gene encodes both mitochondrial (UNG1) and nuclear (UNG2) forms through differentially regulated promotes and alternative splicing. While UNG2 is the major enzyme in the base excision repair pathway that removes uracil residues from nuclear DNA that arise through either misincorporation during replication or cytosine deamination, inhibition of UNG1 by uracil glycosylase inhibitor did not lead to increased levels of spontaneous or induced mitochondrial DNA mutations. However, decreased levels of UNG activity and increased oxidative damage to mitochondrial DNA were seen in older mice, suggesting that mitochondrial DNA repair mechanisms may be involved in various neurodegenerative disorders in an age-dependent manner. This UNG1 antibody will not cross-react with UNG2.

6224979

NP_003353

NM_003362.3

P13051

33,924 Da

Base Excision Repair Pathway 105838!!Base Excision Repair Pathway 83043!!Base Excision Repair Pathway 451!!Base-Excision Repair, AP Site Formation Pathway 105839!!Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway 105848!!Cleavage Of The Damaged Pyrimidine Pathway 105845!!DNA Repair Pathway 105837!!Depyrimidination Pathway 105843!!Displacement Of DNA Glycosylase By APE1 Pathway 105849!!Primary Immunodeficiency Pathway 83125

This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]

0.1 mg

345 USD