ABCA7 Antibody | MyBioSource MBS150228 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

ABCA7 Antibody

catalog :

MBS150228

quantity :

0.1 mg

price :

345 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS150228

products type :

Antibody

products full name :

ABCA7 Antibody

products short name :

ABCA7

products name syn :

ABCX; ABCA-SSN; ATP-binding cassette sub-family A member 7; ATP-binding cassette, sub-family A (ABC1), member 7

other names :

ATP-binding cassette sub-family A member 7; ATP-binding cassette sub-family A member 7; ATP-binding cassette sub-family A member 7; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette, sub-family A (ABC1), member 7; ABCA-SSN; Autoantigen SS-N; Macrophage ABC transporter

products gene name :

ABCA7

other gene names :

ABCA7; ABCA7; ABCX; ABCA-SSN

uniprot entry name :

ABCA7_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

2146

specificity :

ABCA7 antibody is human specific. At least two alternatively spliced transcript variants encoding distinct isoforms have been observed.

purity :

ABCA7 Antibody is affinity chromatography purified via peptide column.

form :

Liquid

concentration :

1 mg/mL

storage stability :

ABCA7 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

tested application :

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

app notes :

ABCA7 antibody can be used for detection of ABCA7 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunocytochemistry starting at 5 mug/mL. For immunofluorescence start at 5 mug/mL.

other info1 :

Conjugate: Unconjugated. Immunogen: ABCA7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human ABCA7. Buffer: ABCA7 Antibody is supplied in PBS containing 0.02% sodium azide.

products description :

ABCA7 Antibody: ATP-binding cassette (ABC) transporters are an evolutionarily conserved family that use ATP hydrolysis to catalyze the transport of various molecules across cell membranes. They are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCA7, a member of the ABC1 subfamily, is a full-size ABC transporter consisting of two sets of the multiple membrane-spanning domains plus the Walker motifs for the ATP interaction. ABCA7 shows the highest homology to ABCA1, an essential molecule for cholesterol homeostasis. The high expression levels of ABCA7 in peripheral leukocytes, thymus, spleen and bone marrow suggests a role in the immune system lipid homeostasis.

ncbi gi num :

150417984

ncbi acc num :

NP_061985

ncbi gb acc num :

NM_019112.3

uniprot acc num :

Q8IZY2

ncbi mol weight :

218,497 Da

ncbi pathways :

ABC Transporters Pathway (83035); ABC Transporters Pathway (436); ABC-family Proteins Mediated Transport Pathway (106573); ABCA Transporters In Lipid Homeostasis Pathway (477112); Transmembrane Transport Of Small Molecules Pathway (106572)

ncbi summary :

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. This full transporter has been detected predominantly in myelo-lymphatic tissues with the highest expression in peripheral leukocytes, thymus, spleen, and bone marrow. The function of this protein is not yet known; however, the expression pattern suggests a role in lipid homeostasis in cells of the immune system. [provided by RefSeq, Jul 2008]

uniprot summary :

ABCA7: Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. Belongs to the ABC transporter superfamily. ABCA family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: Golgi membrane; Golgi apparatus; cell surface; cytoplasm; apical plasma membrane; integral to membrane; plasma membrane; endosome membrane; ATP-binding cassette (ABC) transporter complex; phagocytic cup. Molecular Function: apolipoprotein A-I receptor activity; phospholipid transporter activity; transporter activity; ATPase activity; ATP binding. Biological Process: phospholipid efflux; positive regulation of ATPase activity; positive regulation of phagocytosis; negative regulation of amyloid precursor protein biosynthetic process; cholesterol efflux; peptide cross-linking; phospholipid scrambling; negative regulation of ATPase activity; transmembrane transport; phagocytosis; memory

size1 :

0.1 mg

price1 :

345 USD

more info or order :

MyBioSource product webpage